Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India.
ACS Appl Mater Interfaces. 2024 Sep 11;16(36):47713-47723. doi: 10.1021/acsami.4c10172. Epub 2024 Aug 27.
The extensive use of insecticides, such as pyrethroids, and pharmaceutical drugs, such as doxorubicin (DOX) has significantly increased to meet the growing demand for food production and disease treatment. Among them, 3-phenoxybenzoic acid (3-PBA), a metabolite of pyrethroid insecticides, poses various health and environmental risks. Similarly, DOX is a well-known anticancer drug and has been continuously used for many years. The high demand and unregulated disposal of these substances raise concerns for both humans and the environment. To address this issue, there is a pressing need to monitor the presence of these analytes in wastewater to protect our ecosystems. This challenge has inspired us to develop an MOF-based fluorometric dual sensor capable of rapid and selective detection of these analytes in aqueous solutions. This work represents the first MOF-based dual probe for detecting these targeted analytes. There was a 98% fluorescence quenching upon the introduction of DOX whereas about a 11-fold increment of the probe's fluorescence intensity took place in the presence of 3-PBA. The sensitivity of the probe is notably high as limits of detection (LOD) are 8.7 nM for DOX and 1.2 nM for 3-PBA. Our designed probe has the highest value for DOX which is 3.37 × 10 M. The MOF demonstrated remarkable rapid response time of just 5 and 10 s for DOX and 3-PBA, respectively. The MOF exhibited outstanding selectivity in detecting DOX and 3-PBA, even when other interfering substances were present. We tested the probe's sensing abilities in various environments, such as serum, urine, wastewater, and different pH levels. These findings underscore the sensor's practicality and usefulness in real-world applications. The underlying mechanisms driving the sensing processes were thoroughly investigated by using various modern analytical methods.
拟除虫菊酯等杀虫剂和阿霉素（DOX）等药物的广泛使用，以满足不断增长的粮食生产和疾病治疗需求。其中，拟除虫菊酯杀虫剂的代谢物 3-苯氧基苯甲酸（3-PBA）对健康和环境造成了各种风险。同样，DOX 是一种著名的抗癌药物，多年来一直在不断使用。这些物质的高需求和不受监管的处置引起了人类和环境的关注。为了解决这个问题，迫切需要监测废水中这些分析物的存在，以保护我们的生态系统。这一挑战促使我们开发了一种基于 MOF 的荧光双传感器，能够快速、选择性地检测水溶液中的这些分析物。这项工作代表了第一个基于 MOF 的双探针，用于检测这些目标分析物。当引入 DOX 时，荧光猝灭了 98%，而当存在 3-PBA 时，探针的荧光强度增加了约 11 倍。该探针的灵敏度非常高，检测限（LOD）分别为 8.7 nM 和 1.2 nM。我们设计的探针对 DOX 的 值最高，为 3.37 × 10 M。该 MOF 对 DOX 和 3-PBA 的快速响应时间分别仅为 5 和 10 s。该 MOF 在检测 DOX 和 3-PBA 时表现出出色的选择性，即使存在其他干扰物质也是如此。我们在各种环境中测试了探针的传感能力，如血清、尿液、废水和不同的 pH 值。这些发现突显了传感器在实际应用中的实用性和有用性。通过使用各种现代分析方法，深入研究了驱动传感过程的机制。
