Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran; School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Department of Pathobiology, Faculty of Veterinary Medicine Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Tissue Cell. 2024 Oct;90:102523. doi: 10.1016/j.tice.2024.102523. Epub 2024 Aug 14.
Colon cancer (CC) stands as one of the most common malignancies related to the gastrointestinal system, whose increasing incidence and death rates have been reported all over the world. Standard treatments for fighting cancers like CC comprise surgical approaches, chemotherapy, and radiotherapy, which are suggested by clinicians according to patients' conditions and disease stages. However, patients who utilize these modalities may suffer from serious side effects and adverse outcomes, for example, toxicity and tumor recurrence, as well as a low 5-year survival rate. The present shreds of evidence showed that mesenchymal stem cells (MSCs) can have a suitable capacity for treating different health problems, especially neoplasms. These multipotent stem cells can be isolated from several sources, such as the umbilical cord, bone marrow, adipose tissue, and placenta. Among these mesenchymal sources, umbilical cord-MSCs have gathered much attention in scientific societies due to their advantages (e.g., low immunogenicity, lack of ethical problems, and easy collection). These days, the efficacy of umbilical cord-MSCs and umbilical cord-MSCs-based strategies, such as conditioned medium, extracellular vesicles, and exosomes, on CC have been explored, and promising findings have been stated. Therefore, in this review, we aimed to summarize and debate evidence regarding the effects of UC-MSCs and their related products on CC with a focus on molecular and cellular mechanisms involved in its treatment and pathogenesis of this malignant tumor.
结肠癌（CC）是最常见的胃肠道系统相关恶性肿瘤之一，其发病率和死亡率在全球范围内呈上升趋势。治疗 CC 等癌症的标准方法包括手术、化疗和放疗，这些方法由临床医生根据患者的病情和疾病阶段提出。然而，使用这些方法的患者可能会遭受严重的副作用和不良后果，例如毒性和肿瘤复发，以及 5 年生存率低。目前的证据表明，间充质干细胞（MSCs）具有治疗各种健康问题的合适能力，尤其是肿瘤。这些多能干细胞可以从多种来源分离出来，如脐带、骨髓、脂肪组织和胎盘。在这些间充质来源中，由于其优势（例如低免疫原性、无伦理问题和易于采集），脐带间充质干细胞引起了科学界的广泛关注。如今，已经探索了脐带间充质干细胞及其基于条件培养基、细胞外囊泡和外泌体的策略在 CC 中的疗效，并提出了有前途的发现。因此，在本综述中，我们旨在总结和讨论脐带间充质干细胞及其相关产品对 CC 的影响的证据，重点关注涉及该恶性肿瘤治疗和发病机制的分子和细胞机制。
