Coenzyme R Research Institute, Tehran, Iran.
Department of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Cell Biol Int. 2023 Apr;47(4):714-719. doi: 10.1002/cbin.11991. Epub 2023 Jan 30.
Esophageal cancer (EC), as one of the leading causes of cancer-associated mortality, influences a remarkable population of subjects globally and is histologically divided into two types, comprising esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). Although several therapeutic approaches are present for EC, such as radiotherapy, chemotherapy, and surgery, these options have low success with serious side effects, for example, gastrointestinal toxicity, esophagitis, and pulmonary complications. Thus, utilizing an effective tool with low side effects is urgent. Newly, mesenchymal stem cells (MSCs) have received special interest for treating diverse diseases, such as cancer. Among different sources of MSCs, human umbilical cord MSCs have notable benefits, and reports expressed that they may be effective in EC treatment. For this purpose, in this review study, we aimed to summarize evidence regarding the effects of human umbilical cord MSCs on EC with a mechanistic insight.
食管癌（EC）是癌症相关死亡的主要原因之一，在全球范围内影响着大量人群，其组织学上可分为两种类型，包括食管腺癌（EAC）和食管鳞状细胞癌（ESCC）。尽管存在多种治疗食管癌的方法，如放疗、化疗和手术，但这些方法的成功率较低，且副作用严重，例如胃肠道毒性、食管炎和肺部并发症。因此，迫切需要使用副作用低的有效工具。最近，间充质干细胞（MSCs）因其在治疗多种疾病（如癌症）方面的特殊作用而受到特别关注。在不同来源的 MSCs 中，人脐带 MSCs 具有显著的优势，有报道称其可能对 EC 的治疗有效。为此，在本综述研究中，我们旨在从机制上总结人脐带 MSCs 对 EC 影响的证据。
