Masci E, Testoni P A, Passaretti S, Guslandi M, Tittobello A
Drugs Exp Clin Res. 1985;11(10):687-92.
In the treatment of reflux oesophagitis, either drugs preventing regurgitation of gastric juice in the lower oesophagus or pharmacological agents increasing the pH of the refluxing material are employed. In the present study 45 outpatients with reflux oesophagitis were randomly treated with either ranitidine (150 mg b.i.d.) or domperidone maleate (20 mg t.i.d.) or both drugs for six weeks. Before and after treatment the severity of dyspeptic symptoms and the grade of endoscopic and histological changes were assessed. The three therapeutic regimens were significantly and equally effective in inducing symptomatic relief and promoting endoscopic and histological disappearance or improvement of oesophagitis. The combined use of ranitidine and domperidone maleate failed to show any additional benefit compared with treatment with either drug alone.
在反流性食管炎的治疗中，要么使用防止胃液反流至食管下段的药物，要么使用提高反流物质pH值的药物。在本研究中，45例反流性食管炎门诊患者被随机分为三组，分别接受雷尼替丁（150毫克，每日两次）、马来酸多潘立酮（20毫克，每日三次）治疗，或两种药物联合治疗，为期六周。治疗前后评估消化不良症状的严重程度以及内镜和组织学变化的分级。三种治疗方案在缓解症状、促进内镜及组织学上食管炎的消失或改善方面均有显著且同等的效果。与单独使用任一药物治疗相比，雷尼替丁和马来酸多潘立酮联合使用未显示出任何额外益处。
