Pirprofen in postoperative course following cataract extraction: a controlled trial.

In a double-blind, between-patient trial, a new cyclo-oxygenase inhibitor, pirprofen (800 mg/day), was compared with indomethacin (100 mg/day) and placebo in 56 patients undergoing cataract extraction. Treatment started 48 h before operation and continued for eight days. Patients were examined on days 1, 3 and 6 for objective signs of inflammation and pain. Both active drugs proved to have good anti-inflammatory action, clearly superior to placebo. No unwanted effects or modifications in laboratory parameters other than those related to the antiphlogistic effect were reported.