School of Psychology, The University of Sydney, Sydney, New South Wales, Australia.
Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Eur Neurol. 2024;87(4):177-187. doi: 10.1159/000540340. Epub 2024 Aug 16.
Mounting evidence indicates distinct memory profiles among the primary progressive aphasia (PPA) variants. Neuropsychological tests reveal disproportionate memory impairments in the logopenic variant PPA (lv-PPA) relative to the non-fluent variant PPA (nfv-PPA) and semantic variant PPA (sv-PPA). The real-world experience of day-to-day memory disturbances in PPA, however, remains poorly understood.
Everyday expressions of memory in 26 lv-PPA, 24 nfv-PPA, and 40 sv-PPA patients, and 70 healthy controls were examined using the Cambridge Behavioural Inventory-Revised (CBI-R) carer questionnaire. Kruskal-Wallis tests compared CBI-R Memory items (1-8) across groups. Receiver operating characteristic curves evaluated the most discriminative items to distinguish lv-PPA from nfv-PPA.
Compared to controls, lv-PPA and sv-PPA patients were reported to experience more day-to-day memory issues (item 1), increased repetition of questions (2), forgetting the names of familiar people and objects (4, 5), and poor concentration (6). lv-PPA patients were also reported to exhibit more occurrences of losing or misplacing items (3) and forgetting the day (7). All PPA groups experienced more confusion in unfamiliar environments (8) than controls. Direct comparisons among PPA groups revealed distinct profiles, with lv-PPA and sv-PPA patients exhibiting more frequent forgetting of names and objects (3, 4) than nfv-PPA, and sv-PPA demonstrating greater day-to-day memory impairment (1), repeated questions (2), and poor concentration (6) compared to nfv-PPA. Forgetting the names of familiar objects (5) was the most sensitive and specific item to distinguish lv-PPA from nfv-PPA.
Our findings demonstrate distinct day-to-day memory profiles in PPA. Future research should explore the influence of language impairments on these profiles.
越来越多的证据表明原发性进行性失语症（PPA）的变体存在明显的记忆特征。神经心理学测试显示，与非流利型 PPA（nfv-PPA）和语义型 PPA（sv-PPA）相比，logopenic 型 PPA（lv-PPA）存在不成比例的记忆损伤。然而，PPA 患者日常生活中的记忆障碍的真实体验仍知之甚少。
使用剑桥行为量表修订版（CBI-R）的照顾者问卷，检查 26 例 lv-PPA、24 例 nfv-PPA 和 40 例 sv-PPA 患者以及 70 名健康对照者的日常生活记忆表达。Kruskal-Wallis 检验比较了各组的 CBI-R 记忆项目（1-8）。接收者操作特征曲线评估了最具鉴别力的项目，以区分 lv-PPA 和 nfv-PPA。
与对照组相比，lv-PPA 和 sv-PPA 患者报告说他们在日常生活中遇到更多的记忆问题（项目 1），更多地重复问题（2），忘记熟悉的人和物的名字（4、5），注意力不集中（6）。lv-PPA 患者还报告说，他们更容易出现丢失或放错物品（3）和忘记日期（7）的情况。所有 PPA 组在不熟悉的环境中都经历了更多的困惑（8），比对照组多。对 PPA 组之间的直接比较揭示了不同的模式，lv-PPA 和 sv-PPA 患者比 nfv-PPA 患者更容易忘记名字和物体（3、4），sv-PPA 患者比 nfv-PPA 患者表现出更大的日常记忆损伤（1）、重复问题（2）和注意力不集中（6）。忘记熟悉物体的名字（5）是区分 lv-PPA 和 nfv-PPA 最敏感和最特异的项目。
我们的研究结果表明 PPA 存在不同的日常记忆模式。未来的研究应该探索语言损伤对这些模式的影响。
