Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands; Department of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands.
Neurosci Biobehav Rev. 2018 Sep;92:243-254. doi: 10.1016/j.neubiorev.2018.06.015. Epub 2018 Jun 18.
The distinction between Primary Progressive Aphasia (PPA) variants remains challenging for clinicians, especially for the non-fluent (nfv-PPA) and the logopenic variants (lv-PPA). Previous research suggests that memory tests might aid this differentiation. This meta-analysis compares memory function among PPA variants.
Effects sizes were extracted from 41 studies (N = 849). Random-effects models were used to compare performance on episodic and working memory tests among PPA patients and healthy controls, and between the PPA variants.
Memory deficits were frequently observed in PPA compared to controls, with large effect sizes for lv-PPA (Hedges' g = -2.04 [-2.58 to -1.49]), nfv-PPA (Hedges' g = -1.26 ([-1.60 to -0.92], p < .001)), and the semantic variant (sv-PPA; Hedges' g = -1.23 [-1.50 to -0.97]). Sv-PPA showed primarily verbal memory deficits, whereas lv-PPA showed worse performance than nfv-PPA on both verbal and non-verbal memory tests.
Memory deficits were more pronounced in lv-PPA compared to nfv-PPA. This suggests that memory tests may be helpful to distinguish between these PPA variants.
原发性进行性失语症（PPA）各亚型的区分对临床医生来说仍然具有挑战性，尤其是对于非流利型（nfv-PPA）和语义型（sv-PPA）。先前的研究表明，记忆测试可能有助于区分这些亚型。本荟萃分析比较了 PPA 各亚型的记忆功能。
从 41 项研究中提取效应量（N=849）。采用随机效应模型比较了 PPA 患者和健康对照组以及 PPA 各亚型在情景记忆和工作记忆测试中的表现。
与对照组相比，PPA 患者的记忆缺陷较为常见，且 lv-PPA（Hedges' g = -2.04 [-2.58 至-1.49]）、nfv-PPA（Hedges' g = -1.26 [-1.60 至-0.92]，p<0.001）和语义型（sv-PPA；Hedges' g = -1.23 [-1.50 至-0.97]）的效应量较大。sv-PPA 主要表现为言语记忆缺陷，而 lv-PPA 在言语和非言语记忆测试中的表现均差于 nfv-PPA。
与 nfv-PPA 相比，lv-PPA 的记忆缺陷更为明显。这表明记忆测试可能有助于区分这些 PPA 亚型。
