State Key Laboratory Base of Eco-chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China; Institute of High-Performance Polymers, Qingdao University of Science and Technology, Qingdao 266042, China.
Qingdao Hiser Hospital Affiliated of Qingdao University, Qingdao Traditional Chinese Medicine Hospital, Qingdao 266033, China.
Int J Biol Macromol. 2024 Oct;278(Pt 3):134819. doi: 10.1016/j.ijbiomac.2024.134819. Epub 2024 Aug 16.
Treatment of multiple bacterial infected wounds by eliminating bacteria and promoting tissue regeneration remains a clinical challenge. Herein, dual-network hydrogels (CS-GA/A-β-CD) with snap-structure were designed to achieve curcumin immobilization, using gallic acid-grafted chitosan (CS-GA) and aldehyde-β-cyclodextrin (A-β-CD) crosslinked. A-β-CD were able to achieve rapid dissolution (≥222.35 mg/mL HO), and helped CS-GA/A-β-CD achieve rapid gelation (≤66.23 s). By adjusting the ratio of aldehyde groups of A-β-CD, mechanical properties and drug release can be controlled. CS-GA/A-β-CD/Cur exhibited excellent antimicrobial properties against S. aureus, E. coli, and P. aeruginosa. In vivo experiments demonstrated that CS-GA/A-β-CD/Cur achieved acute bacterial infection wound healing after 20th days, proving its great potential for wound dressing.
治疗多重细菌感染的伤口，既要消除细菌，又要促进组织再生，这仍然是临床面临的挑战。在此，设计了具有卡扣结构的双网络水凝胶（CS-GA/A-β-CD），以实现姜黄素的固定化，使用了接枝有没食子酸的壳聚糖（CS-GA）和醛基-β-环糊精（A-β-CD）交联。A-β-CD 能够实现快速溶解（≥222.35 mg/mL HO），并帮助 CS-GA/A-β-CD 实现快速凝胶化（≤66.23 s）。通过调整 A-β-CD 中醛基的比例，可以控制机械性能和药物释放。CS-GA/A-β-CD/Cur 对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌表现出优异的抗菌性能。体内实验表明，CS-GA/A-β-CD/Cur 在第 20 天实现了急性细菌感染伤口的愈合，证明了其在伤口敷料方面的巨大潜力。
