Nicolaescu Oana Elena, Ionescu Cătălina, Samide Adriana, Tigae Cristian, Spînu Cezar Ionuţ, Oprea Bogdan
Department of Pharmaceutical Technique, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş, 200349 Craiova, Dolj, Romania.
Department of Chemistry, Faculty of Sciences, University of Craiova, 107i Calea București, 200144 Craiova, Dolj, Romania.
Pharmaceutics. 2025 Apr 11;17(4):506. doi: 10.3390/pharmaceutics17040506.
Cyclodextrins (CDs) have largely been investigated during the last decades for their outstanding properties, such as biocompatibility and biodegradability, with wide applications in the pharmaceutical field, among which the formation of inclusion complexes (ICs) with natural or synthetic lipophilic compounds. This review prioritizes the research of recent years (2022-2025), being focused on (1) systematization of the research of ICs based on the structure of the secondary metabolite, namely (i) polyphenols (PPs), (ii) terpenes and terpenoids (TTs), and (iii) alkaloids (Alks); (2) for each type of inclusion complex, the following aspects have been discussed: benefits of complexation, composite materials, and in vitro/in vivo and theoretical studies; and (3) pharmacokinetics and pharmacodynamics, risks, limitations, and perspectives of cyclodextrin inclusion complexes with secondary metabolites.
在过去几十年中，环糊精（CDs）因其出色的性质，如生物相容性和生物降解性，而受到广泛研究，在制药领域有广泛应用，其中包括与天然或合成亲脂性化合物形成包合物（ICs）。本综述重点关注近年来（2022 - 2025年）的研究，着重于：（1）基于次生代谢产物的结构对包合物研究进行系统化，即（i）多酚（PPs）、（ii）萜类和萜类化合物（TTs）以及（iii）生物碱（Alks）；（2）对于每种类型的包合物，讨论了以下方面：络合的益处、复合材料以及体外/体内和理论研究；（3）环糊精与次生代谢产物形成的包合物的药代动力学和药效学、风险、局限性及前景。
