文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

环糊精与生物活性次生代谢产物的复合物及其药物应用的进展

Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications.

作者信息

Nicolaescu Oana Elena, Ionescu Cătălina, Samide Adriana, Tigae Cristian, Spînu Cezar Ionuţ, Oprea Bogdan

机构信息

Department of Pharmaceutical Technique, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş, 200349 Craiova, Dolj, Romania.

Department of Chemistry, Faculty of Sciences, University of Craiova, 107i Calea București, 200144 Craiova, Dolj, Romania.

出版信息

Pharmaceutics. 2025 Apr 11;17(4):506. doi: 10.3390/pharmaceutics17040506.

DOI:10.3390/pharmaceutics17040506
PMID:40284503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12030412/
Abstract

Cyclodextrins (CDs) have largely been investigated during the last decades for their outstanding properties, such as biocompatibility and biodegradability, with wide applications in the pharmaceutical field, among which the formation of inclusion complexes (ICs) with natural or synthetic lipophilic compounds. This review prioritizes the research of recent years (2022-2025), being focused on (1) systematization of the research of ICs based on the structure of the secondary metabolite, namely (i) polyphenols (PPs), (ii) terpenes and terpenoids (TTs), and (iii) alkaloids (Alks); (2) for each type of inclusion complex, the following aspects have been discussed: benefits of complexation, composite materials, and in vitro/in vivo and theoretical studies; and (3) pharmacokinetics and pharmacodynamics, risks, limitations, and perspectives of cyclodextrin inclusion complexes with secondary metabolites.

摘要

在过去几十年中，环糊精（CDs）因其出色的性质，如生物相容性和生物降解性，而受到广泛研究，在制药领域有广泛应用，其中包括与天然或合成亲脂性化合物形成包合物（ICs）。本综述重点关注近年来（2022 - 2025年）的研究，着重于：（1）基于次生代谢产物的结构对包合物研究进行系统化，即（i）多酚（PPs）、（ii）萜类和萜类化合物（TTs）以及（iii）生物碱（Alks）；（2）对于每种类型的包合物，讨论了以下方面：络合的益处、复合材料以及体外/体内和理论研究；（3）环糊精与次生代谢产物形成的包合物的药代动力学和药效学、风险、局限性及前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/90dbc78a62c4/pharmaceutics-17-00506-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/98b86ba9539f/pharmaceutics-17-00506-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/a0e349c9c166/pharmaceutics-17-00506-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/38bbcc510080/pharmaceutics-17-00506-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/c194bda20f2b/pharmaceutics-17-00506-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/ad411b40c7b2/pharmaceutics-17-00506-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/90dbc78a62c4/pharmaceutics-17-00506-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/98b86ba9539f/pharmaceutics-17-00506-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/a0e349c9c166/pharmaceutics-17-00506-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/38bbcc510080/pharmaceutics-17-00506-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/c194bda20f2b/pharmaceutics-17-00506-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/ad411b40c7b2/pharmaceutics-17-00506-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f0d/12030412/90dbc78a62c4/pharmaceutics-17-00506-sch003.jpg

相似文献

[1]
Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications.

Pharmaceutics. 2025-4-11

[2]
Release Characteristics of an Essential Oil Component Encapsulated with Cyclodextrin Shell Matrices.

Curr Drug Deliv. 2021

[3]
Cyclodextrin/surfactant inclusion complexes: An integrated view of their thermodynamic and structural properties.

Adv Colloid Interface Sci. 2021-3

[4]
Cyclodextrin Inclusion of Medicinal Compounds for Enhancement of their Physicochemical and Biopharmaceutical Properties.

Curr Top Med Chem. 2019

[5]
Cyclodextrins as an encapsulation molecular strategy for volatile organic compounds- Pharmaceutical applications.

Colloids Surf B Biointerfaces. 2022-10

[6]
A Review on Cyclodextrins/Estrogens Inclusion Complexes.

Int J Mol Sci. 2023-5-15

[7]
Aggregation of cyclodextrins as an important factor to determine their complexation behavior.

Chem Biodivers. 2006-11

[8]
Cyclodextrins Based Electrochemical Sensors for Biomedical and Pharmaceutical Analysis.

Curr Med Chem. 2017

[9]
Plant polyphenols, terpenes, and terpenoids in oral health.

Open Med (Wars). 2025-4-15

[10]
Mass Spectrometry as a Complementary Approach for Noncovalently Bound Complexes Based on Cyclodextrins.

Adv Exp Med Biol. 2019

引用本文的文献

[1]
The Anti-Angiogenic Effect of L. subsp. Waste Product.

Foods. 2025-7-29

[2]
Physicochemical and Computational Study of the Encapsulation of Resv-4'-LA and Resv-4'-DHA Lipophenols by Natural and HP-β-CDs.

Int J Mol Sci. 2025-8-1

[3]
Patent-Based Technological Overview of Propolis-Cyclodextrin Inclusion Complexes with Pharmaceutical Potential.

Pharmaceutics. 2025-7-11

[4]
Neuroprotective Potential of Betulin and Its Drug Formulation with Cyclodextrin-In Vitro Assessment.

Int J Mol Sci. 2025-6-11

本文引用的文献

[1]
Cyclodextrins: Enhancing Drug Delivery, Solubility and Bioavailability for Modern Therapeutics.

Pharmaceutics. 2025-2-22

[2]
Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence.

Metabolites. 2025-2-13

[3]
An Advanced Combinatorial System from Leaves and Propolis Enhances Antioxidants' Skin Delivery and Fibroblasts Functionality.

Pharmaceuticals (Basel). 2024-11-29

[4]
Cyclodextrins: Advances in Chemistry, Toxicology, and Multifaceted Applications.

Molecules. 2024-11-12

[5]
Kratom Alkaloids: A Blood-Brain Barrier Specific Membrane Permeability Assay-Guided Isolation and Cyclodextrin Complexation Study.

Molecules. 2024-11-9

[6]
Antibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro Against Bacteria, Molecular Docking and MPO-Based Pharmacokinetics Prediction.

Pharmaceutics. 2024-11-18

[7]
Exceptional stability of the sugammadex-solasodine complex: Insights from experimental and theoretical studies.

Carbohydr Polym. 2025-1-15

[8]
Advancements in cyclodextrin-based controlled drug delivery: Insights into pharmacokinetic and pharmacodynamic profiles.

Heliyon. 2024-10-30

[9]
Double-network polyphenol chitosan hydrogels with instant aldehyde-β-cyclodextrin-based structure as potential for treating bacterially infected wounds.

Int J Biol Macromol. 2024-10

[10]
Controlled release characteristics of alkyl gallates and gallic acid from β-cyclodextrin inclusion complexes of alkyl gallates.

Food Chem. 2024-12-1

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索