Ghilardi P L, Casani A
Drugs Exp Clin Res. 1985;11(11):815-8.
Fifty-two adult patients affected by infectious otorhinolaryngological diseases were treated rectally with clofoctol, a new chemotherapeutic phenol derivative. The clinical diagnoses included tonsillitis, paranasal sinus infections, nose and nasopharyngeal infections, external ear canal and middle ear infections. Evaluation of the results was based on clinical and bacteriological data; the effectiveness of the drug was also confirmed by statistical reference to a control group consisting of 52 adult patients affected by otorhinolaryngological infections treated only with topical agents or not treated at all. In the patients treated with clofoctol, good therapeutic results were obtained in over 90% of cases. Only four patients showed mild adverse reactions. On the whole, results demonstrated that clofoctol is very valuable for the management of most of the infectious diseases common in ENT practice.
52例患有感染性耳鼻喉疾病的成年患者接受了新型化疗酚类衍生物氯甲酚的直肠给药治疗。临床诊断包括扁桃体炎、鼻窦感染、鼻和鼻咽感染、外耳道和中耳感染。结果评估基于临床和细菌学数据；通过对由52例仅接受局部用药或未接受任何治疗的感染性耳鼻喉疾病成年患者组成的对照组进行统计学参考，也证实了该药物的有效性。在接受氯甲酚治疗的患者中，超过90%的病例取得了良好的治疗效果。只有4例患者出现了轻微的不良反应。总体而言，结果表明氯甲酚对治疗耳鼻喉科常见的大多数传染病非常有价值。
