Singhal S, Sharma S C, Singhal K C
Department of Otorhinolaryngology, J. N. Medical College, Aligarh Muslim University, U.P.
Indian J Physiol Pharmacol. 1992 Jul;36(3):189-92.
Eighty four patients requiring treatment with Gentamycin were selected from Otorhinolaryngology outpatient and those admitted to the hospital. Patients suffering from hepatic or renal disorders, pregnant women and children were excluded from the study. Seventy three were administered gentamycin 40 mg BD intramuscularly for 7-10 days and in 11 the drug was applied topically as ear drops for 6-12 weeks. Adverse reactions were observed in 9 (13.3%) and 11 (100%) patients given the drug parenterally and topically respectively. In parenteral group incidence was higher in females as compared to males and profile included nausea and vomiting, headache, cough, tinnitis, albuminuria, diminition of hearing and vertigo. Whereas diminition of hearing acuity was observed in all those who had topical application as evidenced by pure tone audiometry.
从耳鼻喉科门诊患者和住院患者中选取84例需要使用庆大霉素治疗的患者。患有肝脏或肾脏疾病的患者、孕妇和儿童被排除在研究之外。73例患者肌肉注射庆大霉素40mg，每日2次，共7 - 10天，11例患者将该药物作为耳滴剂局部应用6 - 12周。分别接受胃肠外给药和局部给药的患者中，有9例（13.3%）和11例（100%）出现了不良反应。在胃肠外给药组中，女性的发生率高于男性，症状包括恶心、呕吐、头痛、咳嗽、耳鸣、蛋白尿、听力减退和眩晕。而通过纯音听力测定证实，所有局部用药的患者均出现了听力敏锐度下降。
