Rogel A, Popliker M, Webb C G, Oren M
Mol Cell Biol. 1985 Oct;5(10):2851-5. doi: 10.1128/mcb.5.10.2851-2855.1985.
The relative levels of mRNA specific for the mouse p53 cellular tumor antigen were determined in various normal adult tissues, embryos, and tumors. All tumors studied contained concentrations of p53 mRNA well above those present in most normal tissues. Normal spleen, however, had p53 mRNA levels comparable to those found in some tumors, despite the fact that they contained barely detectable p53 protein. This apparent discrepancy was found to be due to the extremely rapid turnover rate of p53 in the spleen (half-life, approximately equal to 6 min). In developing fetuses, a marked reduction of p53 mRNA levels was manifest from day 11 onwards, whereas the levels during organogenesis (days 9 to 11) were comparable to those found in undifferentiated embryonic stem cells and in some tumors.
在各种正常成年组织、胚胎和肿瘤中测定了小鼠p53细胞肿瘤抗原特异性mRNA的相对水平。所有研究的肿瘤中p53 mRNA的浓度远高于大多数正常组织中的浓度。然而，正常脾脏的p53 mRNA水平与某些肿瘤中的相当，尽管脾脏中p53蛋白含量几乎检测不到。这种明显的差异被发现是由于脾脏中p53的周转速度极快（半衰期约为6分钟）。在发育中的胎儿中，从第11天起p53 mRNA水平明显降低，而器官形成期（第9至11天）的水平与未分化的胚胎干细胞和某些肿瘤中的相当。
