Benefit delayed immunosenescence by regulating CD4T cells: A promising therapeutic target for aging-related diseases.

CD4T cells play a notable role in immune protection at different stages of life. During aging, the interaction between the body's internal and external environment and CD4T cells results in a series of changes in the CD4T cells pool making it involved in immunosenescence. Many studies have extensively examined the subsets and functionality of CD4T cells within the immune system, highlighted their pivotal role in disease pathogenesis, progression, and therapeutic interventions. However, the underlying mechanism of CD4T cells senescence and its intricate association with diseases remains to be elucidated and comprehensively understood. By summarizing the immunosenescent progress and network of CD4T cell subsets, we reveal the crucial role of CD4T cells in the occurrence and development of age-related diseases. Furthermore, we provide new insights and theoretical foundations for diseases targeting CD4T cell subsets aging as a treatment focus, offering novel approaches for therapy, especially in infections, cancers, autoimmune diseases, and other diseases in the elderly.