Lin Jia-Xin, Chen You-Xin, Chien Min-Cheng, Chen Hsiang-Jou, Lai Chian-Hui, Liang Chien-Fu
Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan.
Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung 402, Taiwan.
J Org Chem. 2024 Sep 6;89(17):12170-12175. doi: 10.1021/acs.joc.4c01054. Epub 2024 Aug 18.
,-Dimethylformamide was reacted with hexamethyldisilazane to generate an ,-dimethylformimidamide intermediate; thereafter, a reaction with acetophenones/β-diketones was induced to form enaminones. The one-pot synthetic protocol described in this paper can be applied to synthesize 1,4-disubstituted 1,2,3-triazoles and 1,4,5-trisubstituted 1,2,3-triazoles, in which organic azides are used as substrates under optimized conditions. Furthermore, this protocol uses readily available materials, is nearly free of solvent, can be applied to gram-scale operations, and leads to the formation of structurally diverse products with favorable yields.
N,N-二甲基甲酰胺与六甲基二硅氮烷反应生成N,N-二甲基甲脒中间体；此后，引发其与苯乙酮/β-二酮反应以形成烯胺酮。本文所述的一锅法合成方案可应用于合成1,4-二取代的1,2,3-三唑和1,4,5-三取代的1,2,3-三唑，其中在优化条件下使用有机叠氮化物作为底物。此外，该方案使用易得的材料，几乎无溶剂，可应用于克级操作，并能以良好的产率形成结构多样的产物。
