Department of Gastroenterology, University of Health Sciences İzmir Bozyaka Training and Education Hospital, İzmir, Türkiye.
Department of Gastroenterology, Bakırçay University Çiğli Training and Education Hospital, İzmir, Türkiye.
Turk J Gastroenterol. 2024 Jul 3;35(8):665-674. doi: 10.5152/tjg.2024.23609.
This study aimed to evaluate the diagnostic efficacy of cell block (CB) and liquid-based cytology (LBC) for endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in pancreatic tumors. The study included patients who underwent EUS-FNA for pancreatic tumors between January 2015 and February 2021 and whose cytology samples were both processed for LBC and CB. Data of 390 patients (220 men, mean age: 64.2 ± 11.4 years) were retrospectively analyzed. Of the detected lesions (size: 17-120 mm; mean: 39.9 ± 13.9 mm), 220 (56.4%) were located in the head and uncinate process of the pancreas. Lesions in 339 (86.9%) patients were diagnosed as malignant using CB and/or LBC and suspicious for malignancy in 44 (11.3%) patients. In 7 patients with non-diagnostic (6 cases) or negative for malignancy (1 case) EUS-FNA results using both methods, the diagnosis of malignancy was established via ultrasound-guided percutaneous biopsy. Malignancy was detected in 324 (92.4%), 313 (87.9%), and 298 (87.9%) patients using CB, LBC, and both CB and LBC, respectively. Final diagnosis was obtained in 339 (98%) patients by using CB and/or LBC. The combined use of the both methods exhibited significantly superior diagnostic accuracy compared with CB and LBC alone (P < .001). Liquid-based cytology and CB exhibit high diagnostic accuracy for the detection of pancreatic tumors in patients undergoing EUS-FNA. The combined use of both methods showed a significantly higher diagnostic accuracy than LBC and CB alone.
本研究旨在评估细胞块（CB）和液基细胞学（LBC）在超声内镜引导下细针抽吸（EUS-FNA）诊断胰腺肿瘤中的诊断效能。研究纳入了 2015 年 1 月至 2021 年 2 月期间因胰腺肿瘤接受 EUS-FNA 检查且细胞学样本同时进行 LBC 和 CB 处理的患者。回顾性分析了 390 例患者（220 例男性，平均年龄：64.2±11.4 岁）的数据。检测到的病变（大小：17-120mm；平均：39.9±13.9mm）中，220 例（56.4%）位于胰头和钩突。339 例（86.9%）患者的 CB 和/或 LBC 诊断为恶性，44 例（11.3%）患者可疑恶性。在 7 例两种方法均未诊断（6 例）或未诊断为恶性（1 例）的 EUS-FNA 结果中，通过超声引导经皮活检确定为恶性。使用 CB、LBC 和 CB 和 LBC 联合检测，分别在 324 例（92.4%）、313 例（87.9%）和 298 例（87.9%）患者中检测到恶性肿瘤。339 例（98%）患者通过使用 CB 和/或 LBC 获得最终诊断。与单独使用 CB 和 LBC 相比，两种方法联合使用的诊断准确性显著更高（P<0.001）。液基细胞学和 CB 对 EUS-FNA 检查的胰腺肿瘤患者具有较高的诊断准确性。两种方法联合使用的诊断准确性显著高于单独使用 LBC 和 CB。
