Washington University in St. Louis School of Medicine, Program in Physical Therapy, St. Louis, MO 63108, USA.
Washington University in St. Louis School of Medicine, Department of Neurology, St. Louis, MO 63108, USA.
Neurodegener Dis Manag. 2024;14(3-4):87-96. doi: 10.1080/17582024.2024.2388507. Epub 2024 Aug 19.
Individuals with Alzheimer disease (AD), Huntington disease (HD) and Parkinson disease (PD) have impaired balance, and comparing these deficits could improve management of neurological diseases. Scores on the Balance Evaluation Systems Test (BESTest) were compared across three groups, consisting of individuals with AD, HD and PD in early stages of their respective disease. Individuals with PD had significantly higher scores on the BESTest than individuals with AD (95% CI [4.30, 21.37], < 0.01) or HD (95% CI [6.53, 24.18], < 0.001). Individuals with AD and HD were not significantly different on the overall BESTest or any of its subsections. AD and HD may have overlapping pathologies resulting in early and similar balance impairments in these groups.
患有阿尔茨海默病(AD)、亨廷顿病(HD)和帕金森病(PD)的个体平衡能力受损,比较这些缺陷可以改善神经系统疾病的管理。比较了三个组的平衡评估系统测试(BESTest)评分,这三个组分别由处于各自疾病早期阶段的 AD、HD 和 PD 个体组成。PD 患者在 BESTest 上的得分明显高于 AD(95%CI [4.30, 21.37],<0.01)或 HD(95%CI [6.53, 24.18],<0.001)患者。AD 和 HD 患者在整体 BESTest 或其任何分项上没有显著差异。AD 和 HD 可能具有重叠的病理学,导致这些组的早期和相似的平衡受损。