Durmuş Gündüz, Karataş Mehmet Baran, Gökalp Murat, Eren Semih, Cebeci Ahmet Ceyhun, Nural Ali, Hatipoğlu Elif, Osken Altuğ, Karaca Mehmet, Zengin Ahmet
Department of Cardiology, Istanbul Dr Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Cardiology, Istanbul, Turkey.
Department of Cardiology, Memorial Atasehir Hospital, Istanbul, Turkey.
Angiology. 2024 Aug 19:33197241273331. doi: 10.1177/00033197241273331.
Atherosclerotic stenosis of the carotid artery contributes significantly to ischemic strokes. This study investigates the correlation between the C-reactive protein (CRP) to albumin ratio (CAR) and in-stent restenosis (ISR) in patients ( = 529) undergoing carotid artery stenting. Patients were categorized based on ISR occurrence. Cox regression analyses were performed to identify independent predictors of ISR. The ISR rate was 10.3%. Laboratory analysis revealed higher levels of uric acid, CRP, and CAR in the ISR group. Cox regression identified CAR as an independent predictor of ISR (Hazard ratio (HR): 1.13, 95% CI: 1.03-1.24, = .01), along with diabetes and smoking. A CAR cut-off of 0.28 predicted ISR with 93% sensitivity and 89% specificity (Area under the curve (AUC): 0.945, 95% CI: 0.923-0.963, < .001). This study establishes a significant association between CAR and ISR in carotid artery stenting patients. The inflammatory response, indicated by CAR, emerges as a crucial factor in ISR development. The study contributes valuable insights into predicting and preventing ISR, emphasizing the potential of CAR as a prognostic biomarker. This easily accessible and cost-effective biomarker could enhance ISR prediction and guide preventive strategies for high-risk patients.
