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腰椎硬膜外阻滞与骶管硬膜外阻滞用于成骨不全患儿下肢截骨术后镇痛的比较:一项单中心9年倾向匹配队列分析

Lumbar Epidural versus Caudal Epidural for Postoperative Analgesia After Lower Extremity Osteotomy Surgery in Pediatric Patients with Osteogenesis Imperfecta: A Propensity-Matched Cohort Analysis in a Single-Center Over 9 Years.

作者信息

Mu Jingjing, Xiong Shiyi, Yang Guixiang, Wang Fengfeng, Li Xuanying, Gao Qiong, Niu Qiang, Wong Stanley Sau Ching, Xu Xuebing, Chan Yauwai, Li Yalan

机构信息

Department of Anesthesiology, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, People's Republic of China.

Department of Anaesthesiology, the University of Hong Kong Shenzhen Hospital, Shenzhen, People's Republic of China.

出版信息

J Pain Res. 2024 Aug 13;17:2645-2656. doi: 10.2147/JPR.S466745. eCollection 2024.

Abstract

PURPOSE

Although pediatric epidural analgesia is a well-established technique used perioperatively. It is unclear whether a lumbar or caudal epidural is suitable for osteogenesis imperfecta (OI) patients, which may be associated with brittle bones and spine deformity. We conducted a retrospective study to investigate and compare the efficacy of the two continuous epidural techniques in pediatric patients undergoing lower extremity osteotomy surgery using a propensity score-matched analysis (PSMA).

PATIENTS AND METHODS

A total of 274 patients were included. Patients' age, weight, and height were adjusted using PSMA. 90 patients were matched for further analysis, with 45 patients in the lumbar epidural group (Group L) and 45 patients in the caudal epidural group (Group C). Pain scores were categorized into three grades: mild (0-3), moderate (4-6), and severe (7-10), and compared between the two groups. Additionally, operation time, operation site, blood loss, scoliosis, oral analgesic medications, and catheter or nerve-related complications were compared.

RESULTS

There were no significant differences in operation time, operation site, scoliosis, and blood loss between the two groups. The percentage of moderate to severe pain during movement was significantly higher in Group L than in Group C, with 37.5% versus 17.5% on the second-day post-operation (P=0.039). However, no statistically significant difference was observed on other days. Additionally, there was no significant difference in oral medication consumption and complications between the two groups.

CONCLUSION

Both lumbar and caudal epidural analgesia can be effectively used postoperatively, and a caudal epidural should be considered where performing a lumbar epidural is challenging in OI pediatric patients.

摘要

目的

虽然小儿硬膜外镇痛是一种在围手术期常用的成熟技术。但尚不清楚腰段或骶管硬膜外麻醉是否适用于成骨不全(OI)患者,这类患者可能伴有骨骼脆弱和脊柱畸形。我们进行了一项回顾性研究,采用倾向评分匹配分析(PSMA)来调查和比较这两种连续硬膜外技术在接受下肢截骨手术的小儿患者中的疗效。

患者与方法

共纳入274例患者。使用PSMA对患者的年龄、体重和身高进行调整。90例患者匹配后进行进一步分析,其中腰段硬膜外组(L组)45例患者,骶管硬膜外组(C组)45例患者。疼痛评分分为三个等级:轻度(0 - 3分)、中度(4 - 6分)和重度(7 - 10分),并在两组之间进行比较。此外,还比较了手术时间、手术部位、失血量、脊柱侧弯、口服镇痛药以及导管或神经相关并发症。

结果

两组在手术时间、手术部位、脊柱侧弯和失血量方面无显著差异。L组术后第二天活动时中重度疼痛的百分比显著高于C组,分别为37.5%和17.5%(P = 0.039)。然而,在其他日期未观察到统计学上的显著差异。此外,两组在口服药物消耗和并发症方面无显著差异。

结论

腰段和骶管硬膜外镇痛术后均可有效使用,在OI小儿患者中,若进行腰段硬膜外麻醉有困难,应考虑采用骶管硬膜外麻醉。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a35/11330249/502aec14c94b/JPR-17-2645-g0001.jpg

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