揭示恶性胃出口梗阻研究中的隐藏结果——来自“胰腺2000”综述的见解
Unveiling hidden outcomes in malignant gastric outlet obstruction research - insights from a "Pancreas 2000" review.
作者信息
Vilas-Boas Filipe, Rizzo Giacomo Emanuele Maria, De Ponthaud Charles, Robinson Stuart, Gaujoux Sebastien, Capurso Gabriele, Vanella Giuseppe, Bozkırlı Bahadır
机构信息
Department of Gastroenterology, São João University Hospital, Porto 4200, Portugal.
Endoscopy Service, Department of Diagnostic and Therapeutic Services, Scientific Institute for Research, Hospitalization and Healthcare - The Mediterranean Institute for Transplantation and Highly Specialized Therapies, Palermo 90127, Sicilia, Italy.
出版信息
World J Gastrointest Endosc. 2024 Aug 16;16(8):451-461. doi: 10.4253/wjge.v16.i8.451.
Malignant gastric outlet obstruction (mGOO) is a major condition affecting patients with periampullary tumors, including pancreatic cancer. The current treatment options include surgical gastroenterostomy, endoscopic stenting and more recently EUS-guided gastroenterostomy. Most studies comparing the outcomes of the three procedures focus on technical success, clinical success and safety. Several "occult" outcomes relevant to the patient's viewpoints and perspective may ultimately impact on cancer-related and overall survival, such as body mass composition, nutritional biomarkers, chemotherapy tolerance and patient-reported quality of life. The aim of this review is to provide an overview of potential key outcomes that should be explored in future comparative research around mGOO treatment options.
恶性胃出口梗阻（mGOO）是一种影响壶腹周围肿瘤患者（包括胰腺癌患者）的主要病症。目前的治疗选择包括外科胃肠吻合术、内镜支架置入术以及最近的超声内镜引导下胃肠吻合术。大多数比较这三种手术效果的研究都集中在技术成功率、临床成功率和安全性上。一些与患者观点和视角相关的“隐性”结果可能最终会影响癌症相关生存率和总生存率，如身体成分、营养生物标志物、化疗耐受性和患者报告的生活质量。本综述的目的是概述在未来围绕mGOO治疗选择的比较研究中应探索的潜在关键结果。
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