Xuan Shuting, Pei Xiaoting, Li Zhijie
Ophthalmology Department, Henan Provincial People's Hospital, Zhengzhou, CHN.
Henan Eye Institute, Henan Provincial People's Hospital, People's Hospital of Henan University, First Affiliated Hospital of Zhengzhou University, Zhengzhou, CHN.
Cureus. 2024 Jul 18;16(7):e64840. doi: 10.7759/cureus.64840. eCollection 2024 Jul.
Corneal dermoid is a congenital benign tumor and ocular malformation, often diagnosed at birth or in early childhood. Its treatment and long-term prognosis remain under-researched, necessitating further investigation.
This study aims to investigate the epidemiological and clinical characteristics of corneal dermoid, evaluate the efficacy of different surgical methods, and identify factors influencing treatment outcomes.
A retrospective analysis was conducted on the clinical data of 58 patients treated for corneal dermoid at our hospital from 2017 to 2021. Patients' demographic information, tumor characteristics, surgical methods, and postoperative outcomes were collected and analyzed. Descriptive statistics, independent sample -test, chi-square ( ) test, and Spearman correlation analysis were used to evaluate the distribution characteristics and intergroup differences of corneal dermoid.
The average age of the patients was 6.3 years, with 55.2% being male and 44.8% female. The right eye was affected in 63.8% of cases, with the temporal limbus being the most common site (75.9%). Pathological examination revealed tumors covered by squamous epithelium, containing hair follicles, sebaceous glands, adipose tissue, and fibrous tissue; some cases also had cartilage and glandular tissue. Surgical methods included corneal dermoid excision (100%), lamellar keratoplasty (37.9%), amniotic membrane grafting (31.0%), and autologous limbal stem cell transplantation (8.6%). None of the 50 followed up patients experienced tumor recurrence. Postoperative vision improved in 58.0% of patients, with more females (61.9%) experiencing visual impairment compared to males (38.1%) (²=4.711, p=0.030).
This study analyzed 58 corneal dermoid patients treated from 2017 to 2021, focusing on epidemiological and clinical characteristics, surgical efficacy, and treatment outcomes. It identified common pathological features and effective surgical methods, with no tumor recurrence in followed up patients. The study highlights the need for further research with larger sample sizes and longer follow-up periods.
角膜皮样瘤是一种先天性良性肿瘤及眼部畸形，常在出生时或儿童早期被诊断出来。其治疗方法及长期预后仍研究不足，需要进一步调查。
本研究旨在调查角膜皮样瘤的流行病学及临床特征，评估不同手术方法的疗效，并确定影响治疗效果的因素。
对2017年至2021年在我院接受角膜皮样瘤治疗的58例患者的临床资料进行回顾性分析。收集并分析患者的人口统计学信息、肿瘤特征、手术方法及术后结果。采用描述性统计、独立样本t检验、卡方（χ²）检验及Spearman相关性分析来评估角膜皮样瘤的分布特征及组间差异。
患者的平均年龄为6.3岁，男性占55.2%，女性占44.8%。63.8%的病例右眼受累，颞侧角膜缘是最常见的部位（75.9%）。病理检查显示肿瘤被鳞状上皮覆盖，包含毛囊、皮脂腺、脂肪组织及纤维组织；部分病例还含有软骨及腺组织。手术方法包括角膜皮样瘤切除术（100%）、板层角膜移植术（37.9%）、羊膜移植术（31.0%）及自体角膜缘干细胞移植术（8.6%）。50例接受随访的患者均未出现肿瘤复发。58.0%的患者术后视力有所改善，女性（61.9%）出现视力损害的比例高于男性（38.1%）（χ²=4.711，p=0.030）。
本研究分析了2017年至2021年接受治疗的58例角膜皮样瘤患者，重点关注流行病学及临床特征、手术疗效及治疗结果。研究确定了常见的病理特征及有效的手术方法，随访患者中无肿瘤复发。该研究强调需要进行更大样本量及更长随访期的进一步研究。
