Joint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Dongxia Road, Shantou, 515041, Guangdong Province, People's Republic of China.
Int Ophthalmol. 2023 Jul;43(7):2273-2282. doi: 10.1007/s10792-022-02623-9. Epub 2023 Jan 14.
To find preoperative simple geometric parameters to predict the outcome of lamellar keratoscleroplasty in patients with corneal limbal dermoids.
We retrospectively analyzed the data of 30 patients with limbal dermoids who underwent lamellar keratoscleroplasty and were followed up for more than 6 months. Seven geometric parameters were used to analyze the relationship with postoperative visual acuity, astigmatism, and scar formation and investigated for their influence on postoperative outcome. These seven parameters included the cornea-invaded area of dermoid, dermoid area, the cornea-invaded length of dermoid, the corneal limbus invaded length of dermoid, dermoid size, bed size, graft size. Furthermore, we divided patients with corneal limbal dermoids into amblyopia group and non-amblyopia group, and analyzed the clinical characteristics of the amblyopia group.
The mean age of the patients at surgery was 10.6 ± 5.83 years. The 7 geometric parameters, preoperative and postoperative astigmatism of the amblyopia group were higher than those of the non-amblyopia group (all P < 0.05). Among the geometric parameters analyzed, the r coefficients between the cornea-invaded length of dermoid and postoperative visual acuity and astigmatism were the highest (r = 0.854, r = 0.714). The r coefficient between the corneal limbus invaded length of dermoid and the postoperative scar was the highest (r = 0.375). The r coefficient between age and postoperative steroid-induced high intraocular pressure was the highest (r = - 0.416). In univariate regression analysis, the cornea-invaded length of dermoid was significantly correlated with postoperative visual acuity (β = 0.270, P < 0.001) and postoperative astigmatism (β = 1.362, P < 0.001). Among the geometric parameters analyzed, the cornea-invaded length of dermoid had best stratified patients in grouping with or without amblyopia (cutoff > 2.24).
The cornea-invaded length of dermoid was the most important related factor of postoperative visual acuity, astigmatism, and amblyopia. The corneal limbus invaded length of dermoid was the most important related factor of postoperative scar formation. The geometric parameters and astigmatism in patients with amblyopia were larger than those in patients without amblyopia.
寻找预测角膜缘部皮样瘤性板层角巩膜成形术预后的术前简单几何参数。
回顾性分析 30 例接受板层角巩膜成形术且随访时间超过 6 个月的角膜缘部皮样瘤患者的资料。使用 7 个几何参数分析与术后视力、散光和瘢痕形成的关系，并探讨其对术后结果的影响。这 7 个参数包括：皮样瘤侵犯角膜的面积、皮样瘤面积、皮样瘤侵犯角膜的长度、皮样瘤侵犯角膜缘的长度、皮样瘤大小、床大小、移植物大小。此外，我们将角膜缘部皮样瘤患者分为弱视组和非弱视组，并分析弱视组的临床特征。
患者手术时的平均年龄为 10.6±5.83 岁。弱视组的 7 个几何参数和术前、术后散光均高于非弱视组（均 P<0.05）。在分析的几何参数中，皮样瘤侵犯角膜的长度与术后视力和散光的 r 系数最高（r=0.854，r=0.714）。皮样瘤侵犯角膜缘的长度与术后瘢痕的 r 系数最高（r=0.375）。年龄与术后类固醇诱导的高眼压的 r 系数最高（r=-0.416）。单因素回归分析显示，皮样瘤侵犯角膜的长度与术后视力（β=0.270，P<0.001）和术后散光（β=1.362，P<0.001）显著相关。在分析的几何参数中，皮样瘤侵犯角膜的长度对是否发生弱视的分组具有最佳分层作用（截点>2.24）。
皮样瘤侵犯角膜的长度是术后视力、散光和弱视最重要的相关因素。皮样瘤侵犯角膜缘的长度是术后瘢痕形成最重要的相关因素。弱视患者的几何参数和散光大于非弱视患者。
