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一例合并感染性关节炎的气性骨髓炎罕见病例。

A Rare Case of Emphysematous Osteomyelitis With Concurrent Septic Arthritis.

作者信息

Brijawi Omar, Hartman Evan, Sharma Sumit, Herbert Mark, Mullowney-Agra Ruth

机构信息

Internal Medicine, Mount Carmel Health System, Grove City, USA.

Internal Medicine, Wright State University Boonshoft School of Medicine, Dayton, USA.

出版信息

Cureus. 2024 Jul 19;16(7):e64898. doi: 10.7759/cureus.64898. eCollection 2024 Jul.

DOI:10.7759/cureus.64898
PMID:39156338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11330587/
Abstract

A rare and possibly fatal infection of the bone called emphysematous osteomyelitis (EO) is caused by the presence of intraosseous gas due to gas-forming organisms. Common gas-producing organisms are in the family or are anaerobes. This gas within bones is most frequently detected using computed tomography (CT) imaging, and prompt diagnosis is important due to the high mortality rate. We present a 76-year-old male who complained of altered mental status, right upper and lower extremity weakness, and lower back pain. The MRI of the lumbar spine showed moderate edema in L3 and L4, with fluid in L3-L4 and L4-L5 concerning discitis/osteomyelitis. A CT-guided biopsy of L3/L4 was then performed by interventional radiology, revealing air present in the L3 and L4 vertebral bodies. Bone cultures from the L3 and L4 vertebra were later positive for that was susceptible to all tested antibiotics, and this was consistent with a diagnosis of vertebral EO. The infectious disease team recommended a six-week course of intravenous ceftriaxone. During the patient's hospital stay, he also developed a septic right knee joint positive for alongwith the concurrent vertebral EO.

摘要

一种罕见且可能致命的骨感染,称为气肿性骨髓炎(EO),是由产气微生物导致的骨内气体存在引起的。常见的产气微生物属于该菌属或为厌氧菌。骨内的这种气体最常通过计算机断层扫描(CT)成像检测到,由于死亡率高,及时诊断很重要。我们报告一名76岁男性,他主诉精神状态改变、右上肢和下肢无力以及下背部疼痛。腰椎磁共振成像(MRI)显示L3和L4有中度水肿,L3 - L4和L4 - L5有液体,提示椎间盘炎/骨髓炎。然后介入放射科对L3/L4进行了CT引导下活检,显示L3和L4椎体存在气体。L3和L4椎体的骨培养后来对该菌呈阳性,该菌对所有测试抗生素敏感,这与椎体EO的诊断一致。感染病团队建议进行为期六周的静脉注射头孢曲松治疗。在患者住院期间,他还并发了右侧膝关节脓毒症,该菌检测呈阳性,同时伴有椎体EO。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce9/11330587/b363432a586e/cureus-0016-00000064898-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce9/11330587/a31d0d9e1bb8/cureus-0016-00000064898-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce9/11330587/b363432a586e/cureus-0016-00000064898-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce9/11330587/a31d0d9e1bb8/cureus-0016-00000064898-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ce9/11330587/b363432a586e/cureus-0016-00000064898-i02.jpg

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本文引用的文献

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J Spine Surg. 2022 Sep;8(3):362-376. doi: 10.21037/jss-22-6.
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Correction to Lancet Infect Dis 2021; online Sept 14. https://doi.org/10.1016/S1473-3099(21)00472-2.
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Lancet Infect Dis. 2021 Dec;21(12):e363. doi: 10.1016/S1473-3099(21)00682-4. Epub 2021 Oct 19.
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Spontaneous emphysematous osteomyelitis of the spine: A case report.脊柱自发性气肿性骨髓炎:一例报告。
Radiol Case Rep. 2020 Jul 5;15(9):1552-1554. doi: 10.1016/j.radcr.2020.05.078. eCollection 2020 Sep.
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Emphysematous Osteomyelitis: Review of the Literature.气肿性骨髓炎:文献回顾。
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