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伏格特-小柳-原田综合征:一例报告

Vogt-Koyanagi-Harada Syndrome: A Case Report.

作者信息

Prathyusha Thummalagunta, Asif Mohammad, Gadde Sai T

机构信息

General Medicine, All India Institute of Medical Sciences, Mangalagiri, Guntur, IND.

出版信息

Cureus. 2024 Jul 16;16(7):e64702. doi: 10.7759/cureus.64702. eCollection 2024 Jul.

Abstract

Vogt-Koyanagi-Harada disease (VKH) is a neurological disorder that impacts vision and hearing by causing the immune system to attack melanocytes. Symptoms of the condition include flu-like symptoms, eye pain, headache, and dizziness, which may progress to vitiligo and hearing impairment. The diagnostic criteria include ocular involvement, generalized choroiditis, tinnitus, meningitis, and skin depigmentation. The treatment includes corticosteroids and immunosuppressive drugs. VKH is believed to be an autoimmune condition, possibly triggered by hereditary factors and cross-reactivity with cytomegalovirus. VKH is common in East Asia and India and has a genetic link to certain alleles. Inflammation generated by Th1 in melanocytes results in the production of granulomas. An analysis of a 48-year-old female with VKH disease revealed symptoms of anterior uveitis and subsequent glaucoma. The treatment involved the administration of systemic steroids and intratympanic steroid injections. Biochemical indicators showed signs of inflammation. Timely identification and therapy are essential for managing VKH. Further research is necessary to enhance outcomes for patients with VKH disease.

摘要

伏格特-小柳-原田病(VKH)是一种神经系统疾病,它通过使免疫系统攻击黑素细胞来影响视力和听力。该病的症状包括类似流感的症状、眼痛、头痛和头晕,这些症状可能会发展为白癜风和听力障碍。诊断标准包括眼部受累、全身性脉络膜炎、耳鸣、脑膜炎和皮肤色素脱失。治疗方法包括使用皮质类固醇和免疫抑制药物。VKH被认为是一种自身免疫性疾病,可能由遗传因素和与巨细胞病毒的交叉反应引发。VKH在东亚和印度很常见,并且与某些等位基因存在遗传联系。黑素细胞中Th1产生的炎症会导致肉芽肿的形成。对一名48岁患有VKH病的女性进行的分析显示出前葡萄膜炎及随后青光眼的症状。治疗包括全身性类固醇给药和鼓室内类固醇注射。生化指标显示有炎症迹象。及时识别和治疗对于管理VKH至关重要。有必要进行进一步研究以改善VKH病患者的治疗效果。

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