Wang Sifan, Kang Yuanbo, He Chunxia, Jin Hongzhong
Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China.
Peking Union Medical College, Chinese Academy of Medical Sciences, Dongdan Santiao 9#, Dongcheng District, Beijing, 100730, China.
World Allergy Organ J. 2024 Jul 20;17(8):100935. doi: 10.1016/j.waojou.2024.100935. eCollection 2024 Aug.
Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DiHS), is a severe type of cutaneous adverse reaction. The gold standard therapy for DRESS involves the discontinuation of the culprit drug, supportive therapies, and administration of corticosteroids. However, in cases of primary treatment failure or suboptimal response, there arises an urgent need for alternative interventions. This review focuses on exploring alternative systemic therapies for patients with steroid-resistant DRESS, steroid-dependent DRESS, or refractory DRESS, encompassing immunosuppressive agents, intravenous immunoglobulin, plasmapheresis, biologics, and small molecule drugs, with an emphasis on their clinical efficacy and the underlying mechanisms in the treatment of DRESS. Furthermore, this review provides a summary of potential management strategies and laboratory workup during the treatment of DRESS.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS），也称为药物性超敏反应综合征（DiHS），是一种严重的皮肤不良反应类型。DRESS的金标准治疗包括停用致病药物、支持性治疗以及给予糖皮质激素。然而，在初始治疗失败或反应欠佳的情况下，迫切需要替代干预措施。本综述着重探讨针对激素抵抗型DRESS、激素依赖型DRESS或难治性DRESS患者的替代全身治疗方法，包括免疫抑制剂、静脉注射免疫球蛋白、血浆置换、生物制剂和小分子药物，重点关注它们在治疗DRESS中的临床疗效和潜在机制。此外，本综述还总结了DRESS治疗期间的潜在管理策略和实验室检查。
