Mu Chao, Chen Li
Department of Psychiatry, The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Psychiatry. 2024 Aug 2;15:1322939. doi: 10.3389/fpsyt.2024.1322939. eCollection 2024.
Common atypical antipsychotics include risperidone, paliperidone, olanzapine, lurasidone, quetiapine, clozapine, aripiprazole, ziprasidone, asenapine, brexpiprazole, and cariprazine. Previous studies on ocular adverse reactions of antipsychotics were mainly focused on typical antipsychotics. Systematic research on atypical antipsychotics remains limited.
This study aimed to evaluate the potential risks of different atypical antipsychotics causing ocular side effects by mining the Food and Drug Administration Adverse Event Reporting System (FAERS) database.
Extract reports from the FAERS from the first quarter of 2016 to the fourth quarter of 2022 were obtained. Data mining of eye disorders associated with atypical antipsychotics was carried out using The Reporting Odds Ratio (ROR) method and The Medicines and Healthcare Products Regulatory Agency (MHRA) method to determine positive signals.
FAERS reports for 9913783 cases were included in these 28 quarters. 64 defined ocular adverse events were classified into 10 categories according to High-Level Group Terms (HLGT).
There were differences in the types and severity of ocular-related adverse events associated with atypical antipsychotics. Ocular neuromuscular-related adverse events were found among all 11 atypical antipsychotics. Olanzapine had the highest signal intensity in oculogyric crisis. Aripiprazole had the highest signal strength in blepharospasm. Cariprazine was associated with cataract-related ocular adverse reactions. In terms of the types of adverse events, our study found that aripiprazole was associated with 28 types of ocular adverse events, followed by quetiapine. Clozapine was only associated with two types of ocular adverse events.
常见的非典型抗精神病药物包括利培酮、帕利哌酮、奥氮平、鲁拉西酮、喹硫平、氯氮平、阿立哌唑、齐拉西酮、阿塞那平、布雷哌唑和卡立普唑。既往关于抗精神病药物眼部不良反应的研究主要集中在典型抗精神病药物上。对非典型抗精神病药物的系统性研究仍然有限。
本研究旨在通过挖掘美国食品药品监督管理局不良事件报告系统（FAERS）数据库，评估不同非典型抗精神病药物引起眼部副作用的潜在风险。
获取2016年第一季度至2022年第四季度FAERS中的报告。使用报告比值比（ROR）方法和英国药品和保健品管理局（MHRA）方法对与非典型抗精神病药物相关的眼部疾病进行数据挖掘，以确定阳性信号。
这28个季度共纳入9913783例FAERS报告。64种明确的眼部不良事件根据高级分组术语（HLGT）分为10类。
与非典型抗精神病药物相关的眼部不良事件在类型和严重程度上存在差异。在所有11种非典型抗精神病药物中均发现了眼部神经肌肉相关不良事件。奥氮平在动眼危象方面的信号强度最高。阿立哌唑在眼睑痉挛方面的信号强度最高。卡立普唑与白内障相关的眼部不良反应有关。在不良事件类型方面，我们的研究发现阿立哌唑与28种眼部不良事件相关，其次是喹硫平。氯氮平仅与两种眼部不良事件相关。
