Al-Nosairy Khaldoon O, Rodenbeck Katharina, Vorholt Sophie, Djouoma Nidele, Thieme Hagen, Müller Fabian, Hoffmann Michael B
Department of Ophthalmology, Faculty of Medicine, Otto-von-Guericke University, Magdeburg, Germany.
Department of Optometry, Berlin University of Applied Sciences and Technology, Berlin, Germany.
Front Med (Lausanne). 2024 Aug 2;11:1419147. doi: 10.3389/fmed.2024.1419147. eCollection 2024.
To investigate the robustness and variability of a novel kinetic visual field (VF) screening method termed rapid campimetry (RC).
In RC visual field (VF) screening is enabled via kinetic-based testing on any computer (10°/4.7 s at 40-cm viewing distance) and high contrast in a dark room (1 cd/cm). In experiment (1): 30 participants [20 healthy participants (HC), 5 glaucoma patients (GLA) and 5 patients with cataract (CAT)] were included to test the intra-session variability (fatigue effect) and the following effects on RC: room illumination (140 cd/m), ±3 D refractive errors, media opacity. In experiment (2): Inter-session variability (1-3 weeks apart) was assessed in 10 HC and 10 GLA. Since RC detects absolute scotomas, the outcome measure was the size of physiological (blindspot) and pathological (glaucoma) scotomas in degrees. A repeated measures ANOVA was employed in experiment 1 and intraclass correlation (ICC) in experiment 2.
Neither the size of the blindspot nor the VF defects differed significantly between the different testing conditions. For intra-session variability, the average bias of blindspot size was -0.6 ± 2.5°, limits of agreement (LOA), in comparison to 0.3 ± 1.5° for VF defects, both with ICC of 0.86 and 0.93, respectively. For the inter-session repeatability, the average bias and LOA for blindspot size was 0.2 ± 3.85° in comparison 1.6 ± 3.1° for VF defects, both with ICC of 0.87 and 0.91, respectively.
RC was robust to suboptimal testing VF conditions and showed good-to-excellent reliability between VF testing visits holding high potential for teleophthalmology.
研究一种名为快速视野计(RC)的新型动态视野(VF)筛查方法的稳健性和变异性。
在RC中,视野(VF)筛查通过在任何计算机上基于动态的测试实现(在40厘米观察距离下为10°/4.7秒),并在暗室中进行高对比度测试(1坎德拉/平方厘米)。在实验(1)中:纳入30名参与者[20名健康参与者(HC)、5名青光眼患者(GLA)和5名白内障患者(CAT)],以测试会话内变异性(疲劳效应)以及以下因素对RC的影响:室内照明(140坎德拉/平方米)、±3屈光度的屈光不正、介质混浊度。在实验(2)中:对10名HC和10名GLA评估了会话间变异性(相隔1 - 3周)。由于RC检测绝对暗点,结果测量指标是生理性(盲点)和病理性(青光眼)暗点的大小(以度为单位)。实验1采用重复测量方差分析,实验2采用组内相关系数(ICC)分析。
不同测试条件下,盲点大小和VF缺陷均无显著差异。对于会话内变异性,盲点大小的平均偏差为 -0.6 ± 2.5°,一致性界限(LOA),相比之下VF缺陷为0.3 ± 1.5°,两者的ICC分别为0.86和0.93。对于会话间重复性,盲点大小的平均偏差和LOA为0.2 ± 3.85°,相比之下VF缺陷为1.6 ± 3.1°,两者的ICC分别为0.87和0.91。
RC对次优测试VF条件具有稳健性,并且在VF测试就诊之间显示出良好至优异的可靠性,在远程眼科方面具有很高的潜力。