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在特立尼达初级保健中使用估算肾小球滤过率(eGFR)和白蛋白肌酐比值作为初始筛查工具以识别慢性肾脏病(CKD)高危人群:一项横断面研究

Using eGFR and Albumin Creatinine Ratio as an Initial Screening Tool in Trinidadian Primary Care to Identify High-risk Population for CKD: A Cross-Sectional Study.

作者信息

Mahadevappa Karthik, Nayak Shivananda B, Maharaj Rohan G, Bhaktha Geetha

机构信息

Faith Hospital, Health Services Authority, Cayman Brac, Cayman Islands.

Department of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences, EWMSC, Mount Hope, Trinidad and Tobago.

出版信息

Indian J Nephrol. 2024 Jul-Aug;34(4):332-337. doi: 10.25259/ijn_451_23. Epub 2024 May 11.

Abstract

BACKGROUND

Chronic kidney disease (CKD) is a major public health burden and is often undiagnosed in the primary care setting. Untested and untreated, this often leads to renal failure and dialysis.

MATERIALS AND METHODS

This was a cross-sectional study of adults aged 20 years and over, diagnosed with type 2 diabetes mellitus and/or hypertension, with no previous history or record of CKD, and attending three chronic disease clinics in the Eastern Regional Health Authority (ERHA). Patients were screened for risk of CKD by using the albumin creatinine ratio. The eGFR was calculated based on serum creatinine by using the CKD Epidemiology Collaboration (EPI) 2009 equation.

RESULTS

In total, 430 patients agreed to participate with 61.2% of response rate. Of the 385 with complete data, 357 (92%) were detected as having a high risk for CKD; older patients (>66 years) and those with both diabetes and hypertension had high proportions of risk for CKD. There were significant associations between age, systolic hypertension, and the severity of risk for CKD.

CONCLUSION

CKD is common at the primary care level among adults with NCDs in Trinidad, with many patients having been left out without being tested for CKD. Primary care physicians must take this into consideration in caring for NCD patients.

摘要

背景

慢性肾脏病(CKD)是一项重大的公共卫生负担,在初级保健环境中常常未被诊断出来。未经检测和治疗,这往往会导致肾衰竭和透析。

材料与方法

这是一项针对20岁及以上成年人的横断面研究,这些成年人被诊断患有2型糖尿病和/或高血压,既往无CKD病史或记录,且在东部地区卫生局(ERHA)的三家慢性病诊所就诊。通过使用白蛋白肌酐比值对患者进行CKD风险筛查。根据血清肌酐,使用慢性肾脏病流行病学合作组织(EPI)2009年方程计算估算肾小球滤过率(eGFR)。

结果

共有430名患者同意参与,应答率为61.2%。在385名有完整数据的患者中,357名(92%)被检测出有CKD高风险;老年患者(>66岁)以及患有糖尿病和高血压的患者CKD风险比例较高。年龄、收缩期高血压与CKD风险严重程度之间存在显著关联。

结论

在特立尼达患有非传染性疾病的成年人中,初级保健层面CKD很常见,许多患者未接受CKD检测。初级保健医生在照顾非传染性疾病患者时必须考虑到这一点。

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