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一氧化二氮作为重氮转移试剂。

Nitrous oxide as diazo transfer reagent.

作者信息

Genoux Alexandre, Severin Kay

机构信息

Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL) 1015 Lausanne Switzerland

出版信息

Chem Sci. 2024 Aug 14;15(34):13605-17. doi: 10.1039/d4sc04530k.

DOI:10.1039/d4sc04530k
PMID:39156938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11323477/
Abstract

Nitrous oxide, commonly known as "laughing gas", is formed as a by-product in several industrial processes. It is also readily available by thermal decomposition of ammonium nitrate. Traditionally, the chemical valorization of NO is achieved oxidation chemistry, where NO acts as a selective oxygen atom transfer reagent. Recent results have shown that NO can also function as an efficient diazo transfer reagent. Synthetically useful methods for synthesizing triazenes, N-heterocycles, and azo- or diazo compounds were developed. This review article summarizes significant advancements in this emerging field.

摘要

一氧化二氮，俗称“笑气”，是在多个工业过程中作为副产物形成的。它也可通过硝酸铵的热分解轻松获得。传统上，一氧化氮的化学增值是通过氧化化学实现的，其中一氧化氮作为选择性氧原子转移试剂。最近的研究结果表明，一氧化氮还可以作为一种有效的重氮转移试剂。开发了用于合成三氮烯、氮杂环以及偶氮或重氮化合物的具有合成实用性的方法。这篇综述文章总结了这一新兴领域的重大进展。

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