Munir Tariq, Mahmood Arslan, Abbas Numan, Sohail Amjad, Khan Yasin, Rasheed Saba, Ali Irfan
Department of Physics, Government College University Faisalabad (GCUF), Allama Iqbal Road, Faisalabad 38000, Pakistan.
College of Physics and Information Technology, Shaanxi Normal University, Xian 710119, Shaanxi, PR China.
ACS Omega. 2024 Jul 29;9(32):34841-34847. doi: 10.1021/acsomega.4c04183. eCollection 2024 Aug 13.
The current research is related to the synthesis of different concentrations (0, 3, and 7 wt %) Zn doped TiO-NPs by using the coprecipitation method. The rutile, anatase crystal structure appeared on different diffracted peaks in TiO-NPs, and the crystallite size (12 to 24 nm) was calculated by using XRD analysis. The spherical, irregular, porous grain-like surface morphology was observed by SEM analysis, and the identification of different functional modes such as hydroxyl, -C-O, -C-O-C, and Ti-O-Ti attached on the surface of the spectrum was examined via FTIR analysis. After that, the increased absorbance of TiO-NPs by increasing the Zn concentration in TiO-NPs was observed by UV-visible analysis. After that, the well diffusion method was performed to measure antibacterial activity, and the MTT assay was used to investigate anticancer activity against the HepG2 cell line. It was observed that the inhibition zone of and increased by increasing the concentration of Zn-doped TiO-NPs from 2 to 32 mm. The 7 wt % Zn-doped TiO-NPs provided significant anticancer activity against the liver cancer cell line and antibacterial activity. In the future, Zn doped TiO-NPs can be used for in vitro analysis against different microbial and animal models for the treatment of cancer.
当前的研究涉及通过共沉淀法合成不同浓度（0、3和7 wt%）的锌掺杂二氧化钛纳米颗粒（Zn doped TiO-NPs）。在TiO-NPs的不同衍射峰上出现了金红石型和锐钛矿型晶体结构，通过X射线衍射（XRD）分析计算出微晶尺寸（12至24纳米）。通过扫描电子显微镜（SEM）分析观察到球形、不规则、多孔颗粒状的表面形态，并通过傅里叶变换红外光谱（FTIR）分析检测了光谱表面附着的不同功能模式，如羟基、-C-O、-C-O-C和Ti-O-Ti。之后，通过紫外可见分析观察到随着TiO-NPs中锌浓度的增加，TiO-NPs的吸光度增加。之后，采用平板扩散法测量抗菌活性，并使用MTT法研究对肝癌细胞系（HepG2）的抗癌活性。观察到随着锌掺杂TiO-NPs浓度从2增加到32毫米，抑菌圈增大。7 wt%的锌掺杂TiO-NPs对肝癌细胞系具有显著的抗癌活性和抗菌活性。未来，锌掺杂TiO-NPs可用于针对不同微生物和动物模型的体外分析，以用于癌症治疗。
