Lee Wismmy, Chaudhary Fihr, Agrawal Devendra K
Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona CA 91766, USA.
J Environ Sci Public Health. 2024;8(2):101-115. doi: 10.26502/jesph.96120209. Epub 2024 Jun 13.
The health outcomes of an individual are shaped by a combination of genetic predisposition and environmental influences. While some diseases stem solely from environmental factors, others like atopic eczema, also known as neurodermatitis or atopic dermatitis, are multifaceted, with environmental variables playing a significant role in its initiation and severity. Atopic eczema is a prevalent chronic condition observed globally, particularly in Western industrialized nations where its prevalence is estimated to range from 2.5% to 3.5% in adults and 10% to 15% among children. The increasing incidence of atopic eczema in industrialized countries over recent decades suggests that this trend may be due to environmental changes rather than genetic predispositions. Therefore, by thoroughly examining environmental factors and their role in atopic dermatitis, one may be able to gain a better understanding of its disease pattern and develop possible preventative measures. This article provides a comprehensive analysis of how the surrounding environment contributes to the pathogenesis of atopic eczema.
个体的健康状况是由遗传易感性和环境影响共同塑造的。虽然有些疾病完全源于环境因素,但其他疾病,如特应性湿疹(也称为神经性皮炎或特应性皮炎),则是多方面的,环境变量在其发病和严重程度中起着重要作用。特应性湿疹是一种在全球范围内普遍存在的慢性疾病,尤其在西方工业化国家,据估计其在成年人中的患病率为2.5%至3.5%,在儿童中的患病率为10%至15%。近几十年来,工业化国家特应性湿疹的发病率不断上升,这表明这种趋势可能是由于环境变化而非遗传易感性。因此,通过深入研究环境因素及其在特应性皮炎中的作用,人们可能能够更好地了解其疾病模式并制定可能的预防措施。本文全面分析了周围环境如何促成特应性湿疹的发病机制。