微小RNA在特应性皮炎发病机制中的作用
The Role of MicroRNA in the Pathogenesis of Atopic Dermatitis.
作者信息
Gołuchowska Natalia, Ząber Aldona, Będzichowska Agata, Tomaszewska Agata, Rustecka Agnieszka, Kalicki Bolesław
机构信息
Department of Pediatrics, Pediatric Nephrology and Allergology, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland.
Faculty of Medicine, University of Warsaw, 02-089 Warsaw, Poland.
出版信息
Int J Mol Sci. 2025 Jun 18;26(12):5846. doi: 10.3390/ijms26125846.
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczematous lesions and recurrent pruritus. The pathogenesis of AD involves epidermal barrier impairments, immune dysfunction, and both genetic and environmental factors. This review presents the latest findings regarding the involvement of microRNA (miRNA) molecules in AD pathogenesis and their potential application as diagnostic biomarkers and therapeutic targets. The following miRNAs were analyzed in detail: miR-223, miR-10a-5p, miR-29b, miR-146a-5p, miR-451a, miR-124, miR-143, miR-151a, miR-24, miR-191, and miR-155. Their molecular mechanisms and potential clinical implications are discussed. Understanding the role of specific microRNAs in AD pathogenesis may contribute to the development of new diagnostic and therapeutic strategies for this disease.
特应性皮炎（AD）是一种慢性炎症性皮肤病，其特征为湿疹样皮损和反复瘙痒。AD的发病机制涉及表皮屏障受损、免疫功能障碍以及遗传和环境因素。本综述介绍了有关微小RNA（miRNA）分子参与AD发病机制的最新研究结果及其作为诊断生物标志物和治疗靶点的潜在应用。详细分析了以下miRNA：miR-223、miR-10a-5p、miR-29b、miR-146a-5p、miR-451a、miR-124、miR-143、miR-151a、miR-24、miR-191和miR-155。讨论了它们的分子机制和潜在的临床意义。了解特定微小RNA在AD发病机制中的作用可能有助于开发针对该疾病的新诊断和治疗策略。
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