Song Zhengxi, Zhang Shan, Pan HongYu, Hu Bingshuang, Liu XinLian, Cui Jia, Zhang LuShun
Department of Neurology, The People' s Hospital of Jianyang city, Jianyang, 641400 China.
School of Clinical Medicine, Chengdu Medical College, Chengdu, 610500, China.
Heliyon. 2024 Jul 19;10(15):e34720. doi: 10.1016/j.heliyon.2024.e34720. eCollection 2024 Aug 15.
The global incidence of neurological diseases has been on the rise, creating an urgent need for a validated marker. Neurofilament Light Chain (NfL) holds promise as such a marker and has garnered significant attention in the field of neurological diseases over the past decades.
Corresponding articles from 2013 to 2023 were collected from the Web of Science database, and data were analyzed by CiteSpace and VOSviewer software.
A total of 1350 articles were collected from 296 countries/regions, involving 7246 research organizations. Since 2013, among the top ten institutions and authors with the highest number of published papers, the most are from the US and the UK. The United States leads in the number of published papers, but England holds a more momentous position, because it has higher IF. Henrik Zetterberg is the most influential scholar in the field.
The output of papers mainly relies on researchers from developed countries, and scholars from the United States and England have contributed the largest number of papers. Until now, the importance of NfL in neurological diseases has attracted global attention. In addition, NfL contributes to the potential diagnosis of various neurological disorders and can be used to improve the accuracy of differential diagnosis and prognostic assessment as well as predict the response to treatments. More and more in-depth studies are highly needed in the future.
全球神经系统疾病的发病率呈上升趋势，迫切需要一种经过验证的标志物。神经丝轻链（NfL）有望成为这样一种标志物，在过去几十年里在神经系统疾病领域受到了广泛关注。
从科学网数据库收集2013年至2023年的相关文章，并使用CiteSpace和VOSviewer软件进行数据分析。
共收集了来自296个国家/地区的1350篇文章，涉及7246个研究机构。自2013年以来，在发表论文数量最多的前十所机构和作者中，大多数来自美国和英国。美国发表的论文数量最多，但英国的地位更为重要，因为其论文的影响因子更高。亨里克·泽特贝里是该领域最有影响力的学者。
论文产出主要依赖于发达国家的研究人员，美国和英国的学者贡献的论文数量最多。到目前为止，NfL在神经系统疾病中的重要性已引起全球关注。此外，NfL有助于各种神经系统疾病的潜在诊断，可用于提高鉴别诊断和预后评估的准确性以及预测治疗反应。未来迫切需要开展越来越深入的研究。
