Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, China.
Front Immunol. 2024 Jul 3;15:1390149. doi: 10.3389/fimmu.2024.1390149. eCollection 2024.
Neuroinflammation represents the immune response of the central nervous system to nerve injury, infection, toxin stimulation, or autoimmunity and is implicated in a wide range of neurological disorders. Viruses play a pivotal role as extrinsic biological drivers in neuroinflammation; however, numerous aspects remain unexplored. In this study, we employed bibliometric analysis to assess the current status of viral research in neuroinflammation and anticipate future research directions and emerging trends.
Conduct a comprehensive search for scholarly publications within the Web of Science Core Collection database, with search terms on neuroinflammation and virus. Apply Microsoft Excel Office, Hiplot, R (version 4.3.1), VOSviewer (version 1.6.20) and CiteSpace (6.2.R6, advanced) software for the bibliometric analysis and visualization.
A total of 4230 articles and reviews on virus and neuroinflammation were identified, demonstrating a consistent upward trend over time. The United States was the country that contributed the most publications. Approximately 22274 authors from 4474 institutions contributed to the research. Johns Hopkins University leads with the highest number of publications and citations. The top three authors with the most published articles on this field are Power, C., Lane, T. E., and Buch, S. The Journal of Neuroinflammation is the most authoritative choice for researchers. The main research focuses in this field include multiple sclerosis, Parkinson's disease, blood-brain barrier, COVID-19, Alzheimer's disease, gene therapy. In recent years, stress have emerged as hot keywords, particularly depression, human immunodeficiency virus-associated neurocognitive disorders, blood-brain barrier, gut microbiota related directions, indicating a potential shift in research focus.
Research on the virus and neuroinflammation has attracted increasing attention in the past decade. European and American countries have been pivotal in conducting research on virus and neuroinflammation, while China has produced a significant number of publications, its impact is still limited. Stress is likely to emerge as the next area of focus in this field. The association and regulation between viral infection and psychiatric disorders are not fully understood, and further research is needed to explore the role of neuroinflammation caused by different types of viral infection and psychiatric disorders.
神经炎症代表中枢神经系统对神经损伤、感染、毒素刺激或自身免疫的免疫反应，与广泛的神经疾病有关。病毒作为神经炎症的外在生物驱动因素起着关键作用；然而，仍有许多方面尚未得到探索。在这项研究中，我们采用文献计量学分析评估病毒在神经炎症中的研究现状，并预测未来的研究方向和新兴趋势。
在 Web of Science 核心合集数据库中进行有关神经炎症和病毒的学术出版物的全面检索，使用神经炎症和病毒的检索词。应用 Microsoft Excel Office、Hiplot、R（版本 4.3.1）、VOSviewer（版本 1.6.20）和 CiteSpace（6.2.R6，高级）软件进行文献计量分析和可视化。
共确定了 4230 篇关于病毒和神经炎症的文章和综述，表明随着时间的推移呈持续上升趋势。美国是发表文献最多的国家。来自 4474 个机构的约 22274 名作者为该研究做出了贡献。约翰霍普金斯大学发表的文献和引用量最高。在该领域发表文章最多的前三位作者是 Power，C.，Lane，T. E. 和 Buch，S. 期刊《神经炎症杂志》是研究人员的首选。该领域的主要研究重点包括多发性硬化症、帕金森病、血脑屏障、COVID-19、阿尔茨海默病、基因治疗。近年来，压力已成为热门关键词，尤其是抑郁、人类免疫缺陷病毒相关神经认知障碍、血脑屏障、肠道微生物群相关方向，表明研究重点可能发生转移。
过去十年，病毒与神经炎症的研究受到了越来越多的关注。欧洲和美国在病毒与神经炎症的研究中发挥了关键作用，而中国发表的文献数量较多，但影响力仍有限。压力可能成为该领域的下一个重点。病毒感染与精神疾病之间的关联和调节尚不完全清楚，需要进一步研究来探索不同类型的病毒感染和精神疾病引起的神经炎症的作用。
