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Constitutive androstane receptor: A tumor suppressor and a biomarker for favorable prognosis of liver diseases.

作者信息

Da Won Bae Sarah, Nguyen Romario, Yuen Lawrence, Lam Vincent, George Jacob, Qiao Liang

机构信息

Storr Liver Centre, Westmead Institute for Medical Research, University of Sydney, and Westmead Hospital, Westmead, NSW 2145, Australia.

Department of Surgery, Westmead Hospital, Westmead, NSW 2145, Australia.

出版信息

Genes Dis. 2023 Dec 19;11(6):101198. doi: 10.1016/j.gendis.2023.101198. eCollection 2024 Nov.

DOI:10.1016/j.gendis.2023.101198
PMID:39157456
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11327506/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/11327506/6b1f35b45df4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/11327506/6b1f35b45df4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/11327506/6b1f35b45df4/gr1.jpg

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Constitutive androstane receptor: A tumor suppressor and a biomarker for favorable prognosis of liver diseases.组成型雄烷受体：一种肿瘤抑制因子及肝病预后良好的生物标志物。
Genes Dis. 2023 Dec 19;11(6):101198. doi: 10.1016/j.gendis.2023.101198. eCollection 2024 Nov.
2
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Basic Clin Pharmacol Toxicol. 2006 May;98(5):480-7. doi: 10.1111/j.1742-7843.2006.pto_261.x.
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Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways.黄芩素、黄芩苷、绿原酸和人参皂苷 Rf 通过组成型雄烷受体和妊娠相关 X 受体介导途径诱导 CYP3A4 和 MDR1 基因表达。
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Induction of Constitutive Androstane Receptor during the Development of Oxidative Stress.诱导型雄烷受体在氧化应激发展过程中的作用。
Bull Exp Biol Med. 2021 Sep;171(5):615-618. doi: 10.1007/s10517-021-05280-7. Epub 2021 Oct 9.
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Constitutive androstane receptor (CAR) mediates pyrene-induced inflammatory responses in mouse liver, with increased serum amyloid A proteins and Th17 cells.组成型雄烷受体（CAR）介导芘诱导的小鼠肝脏炎症反应，导致血清淀粉样蛋白 A 蛋白和 Th17 细胞增加。
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Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.在肝脏肿瘤发生过程中和肝脏肿瘤中，多个基因表现出苯巴比妥诱导的组成型活性/雄烷受体介导的DNA甲基化变化。
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Differential Effects of Components in Artemisia annua Extract on the Induction of Drug-Metabolizing Enzyme Expression Mediated by Nuclear Receptors.青蒿提取物成分对核受体介导的药物代谢酶表达诱导的差异影响。
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The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism.核受体孕烷 X 受体和组成型雄烷受体有助于氟虫腈对与甲状腺激素代谢相关的肝脏基因表达的影响。
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Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially yes-associated protein activation.组成型雄烷受体诱导的肝肿大和肝再生部分是Yes相关蛋白激活所致。
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引用本文的文献

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Constitutive androstane receptor (CAR) functions as a tumor suppressor via regulating stemness in liver cancer.组成型雄烷受体（CAR）通过调节肝癌干细胞特性发挥肿瘤抑制作用。
Sci Rep. 2024 Dec 28;14(1):30926. doi: 10.1038/s41598-024-81571-z.

本文引用的文献

1
Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling.人组成型雄烷受体通过抑制促红细胞生成素信号传导来抑制肝癌发展和肝癌细胞增殖。
J Biol Chem. 2022 May;298(5):101885. doi: 10.1016/j.jbc.2022.101885. Epub 2022 Mar 30.
2
Role of the constitutive androstane receptor (CAR) in human liver cancer.组成型雄烷受体（CAR）在人肝癌中的作用。
Biochim Biophys Acta Rev Cancer. 2021 Apr;1875(2):188516. doi: 10.1016/j.bbcan.2021.188516. Epub 2021 Jan 30.
3
Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells.
组成型雄烷受体激动剂 CITCO 抑制脑肿瘤干细胞的生长和扩增。
Br J Cancer. 2011 Feb 1;104(3):448-59. doi: 10.1038/sj.bjc.6606064. Epub 2011 Jan 11.
4
A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.核激素受体超家族的一个新的孤儿成员，它与一部分视黄酸反应元件相互作用。
Mol Cell Biol. 1994 Mar;14(3):1544-52. doi: 10.1128/mcb.14.3.1544-1552.1994.