Ryazan State Medical University, Ministry of the Health of the Russian Federation, Ryazan, Russia.
Bull Exp Biol Med. 2021 Sep;171(5):615-618. doi: 10.1007/s10517-021-05280-7. Epub 2021 Oct 9.
We studied the effect of 3-, 24-, and 72-h exposure to HO in concentrations of 0.1-100.0 μM on the level of constitutive androstane receptor in Caco-2 cells. It was shown that 3- and 24-h incubation with НО in all concentrations had no effect on the level of constitutive androstane receptors. Increasing the incubation time to 72 h led to an increase in the level of constitutive androstane receptor at HO concentrations of 5, 10, and 50 μM and to a decrease at a concentration of 100 μM. Antioxidant glutathione (1 mM) in parallel to the prooxidant neutralized these changes.
我们研究了 3、24 和 72 小时暴露于 0.1-100.0 μM HO 浓度对 Caco-2 细胞中组成型雄烷受体水平的影响。结果表明，在所有浓度下，3 小时和 24 小时孵育对组成型雄烷受体水平没有影响。将孵育时间延长至 72 小时导致在 5、10 和 50 μM HO 浓度下组成型雄烷受体水平增加，而在 100 μM 浓度下水平降低。抗氧化剂谷胱甘肽（1mM）与促氧化剂一起中和了这些变化。
