Abdelrahim Sara, Thai Glory H, Burke Juanita, O'Brien Timothy, Ansari Mohammad Q, Zhao Chen, Sakr Hany
Department of Pathology Louis Stokes Veterans Affairs Medical Center Cleveland Ohio USA.
School of Medicine Case Western Reserve University Cleveland Ohio USA.
EJHaem. 2024 Jun 21;5(4):845-850. doi: 10.1002/jha2.958. eCollection 2024 Aug.
CD4+ chronic lymphocytic leukemia (CLL) represents an extremely rare example of phenotypic aberrancy within CLL. We present a case of an 86-year-old male veteran with a history of multiple comorbidities who was incidentally diagnosed with CD4+ CLL during a routine peripheral blood workup. This case highlights the diagnostic challenges and characteristic features of CD4+ CLL, including flow cytometric analysis, molecular, and fluorescence in situ hybridization findings. The patient was classified as asymptomatic CLL Rai stage 0, warranting regular monitoring without a need for treatment intervention.
CD4+慢性淋巴细胞白血病（CLL）是CLL中一种极为罕见的表型异常情况。我们报告一例86岁男性退伍军人病例，该患者有多种合并症病史，在常规外周血检查中偶然被诊断为CD4+CLL。本病例突出了CD4+CLL的诊断挑战和特征，包括流式细胞术分析、分子及荧光原位杂交结果。该患者被分类为无症状CLL Rai 0期，只需定期监测，无需治疗干预。
