Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, People's Republic of China.
Zhejiang Provincial Key Lab of Hematopoietic Malignancy, Zhejiang University, Hangzhou, Zhejiang, 310003, People's Republic of China.
Biomed Eng Online. 2022 Jan 11;21(1):4. doi: 10.1186/s12938-021-00973-6.
Chronic lymphocytic leukemia (CLL) is the most prevalent subtype of leukemia in Western countries, causing a substantial health burden on patients and society. Comprehensive evaluation of the epidemiological characteristics of CLL is warranted, especially in the current context of global population aging. The main objective of this study is evaluating the disease burden of CLL at global, regional, and national levels from 1990 to 2019. As secondary objectives, we studied the influence of demographic factors and performed risk factor analysis. We hope this study could provide evidence for the evaluation of the effectiveness of previous prevention strategies and the formulation of future global health policies.
Based on data of CLL between 1990 to 2019 from the Global Burden of Disease (GBD) study 2019, we depicted the age, gender, and regional structure of the CLL burden population and described the impact of social development on the disease burden of CLL. The distribution and changing trends of attributable risk factors were also investigated. The global burden of CLL has increased dramatically. A high incidence has been achieved in males and elder people. Countries and territories with high social-demographic index (SDI) tended to have higher global burden than low-SDI region. Of risk factors, high body mass index and smoking were the major contributors for CLL-related mortality and disability adjusted life-years (DALYs).
In summary, the global CLL burden continues to rise over the past 30 years. The relocation of medical resource should be considered on a global scale.
慢性淋巴细胞白血病（CLL）是西方国家最常见的白血病亚型，给患者和社会带来了巨大的健康负担。有必要全面评估 CLL 的流行病学特征，尤其是在当前全球人口老龄化的背景下。本研究的主要目的是评估 1990 年至 2019 年全球、区域和国家层面 CLL 的疾病负担。作为次要目标，我们研究了人口因素的影响并进行了危险因素分析。我们希望本研究能为评估以往预防策略的效果和制定未来全球卫生政策提供依据。
基于 2019 年全球疾病负担（GBD）研究中 1990 年至 2019 年 CLL 的数据，我们描述了 CLL 负担人群的年龄、性别和区域结构，并描述了社会发展对 CLL 疾病负担的影响。还调查了归因危险因素的分布和变化趋势。CLL 的全球负担显著增加。男性和老年人的发病率较高。社会人口指数（SDI）较高的国家和地区的全球负担往往高于 SDI 较低的地区。在危险因素中，高体重指数和吸烟是导致 CLL 相关死亡和伤残调整生命年（DALYs）的主要因素。
总之，过去 30 年来，全球 CLL 负担持续上升。应该在全球范围内考虑医疗资源的重新配置。
