Sherratt-Mayhew Sam, Nicolson Phillip L R
Institute of Cardiovascular Sciences University of Birmingham Birmingham UK.
Department of Haematology University Hospitals Birmingham NHS Foundation Trust Birmingham UK.
EJHaem. 2024 Jun 16;5(4):825-828. doi: 10.1002/jha2.937. eCollection 2024 Aug.
Pure red cell aplasia (PRCA) is characterised by normocytic normochromic anaemia, reticulocytopenia and reduced erythroid precursors in bone marrow. PRCA as an immune-related adverse event secondary to immune checkpoint inhibitor (ICI) therapy is rare. Steroids are usually used first line to treat ICI-induced PRCA. Here, we report a case of ICI-induced PRCA with no response to steroids but where intravenous (IV) immunoglobulin was successfully used second line. ICI therapy was reinitiated following PRCA resolution. PRCA recurrence did not occur.
纯红细胞再生障碍性贫血（PRCA）的特征为正细胞正色素性贫血、网织红细胞减少以及骨髓中红系前体细胞减少。PRCA作为免疫检查点抑制剂（ICI）治疗继发的免疫相关不良事件较为罕见。类固醇通常作为一线药物用于治疗ICI诱发的PRCA。在此，我们报告一例ICI诱发的PRCA患者，该患者对类固醇治疗无反应，但二线使用静脉注射免疫球蛋白成功治愈。PRCA缓解后重新开始ICI治疗，未出现PRCA复发。
