Ren Jing, Zhou Jiahua, Wang Qinhui, Liu Linna, Liu Wei, Wang Shan, Zheng Yao, Luo Li, Yang Qi
Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, People's Republic of China.
Department of Neurosurgery, The Second Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, People's Republic of China.
Infect Drug Resist. 2024 Aug 12;17:3483-3490. doi: 10.2147/IDR.S473392. eCollection 2024.
Aseptic abscess (AA) syndrome is a rare inflammatory disorder often associated with inflammatory bowel disease (IBD). Cases of IBD-associated AA have been reported in Japan, India, and Canada, but rarely in China. Herein, we present the case of a Chinese patient with IBD-associated AAs and review the literature on AA with underlying IBD. We report the case of a 48-year-old male patient with multiple AAs on his left hand and lungs who was successfully treated with prednisone. He had undergone cutaneous abscess incision and drainage twice in the previous 2 years. The patient presented to our hospital with ulcerative colitis and pain in the dorsum of the left hand. Pus from his hand and blood cultures revealed sterile cutaneous abscesses. Chest computed tomography examination during hospitalization revealed a lung abscess. The AA was unresponsive to cefotiam or cefoperazone-sulbactam. The patient's left hand and lung conditions did not improve until prednisone was administered. The patient was followed up as an outpatient for 3 months and recovered without any clinical symptoms. We retrieved 17 cases of IBD-associated AA from the literature. None of the patients showed evidence of infection and failed antibiotic treatment, and all improved with corticosteroid use. AA may be an extra-intestinal manifestation of IBD. Effective medications include corticosteroids and immunosuppressive agents. This case may increase the awareness of AA and aid in early identification.
无菌性脓肿（AA）综合征是一种罕见的炎症性疾病，常与炎症性肠病（IBD）相关。日本、印度和加拿大均有IBD相关AA病例的报道，但在中国较为罕见。在此，我们报告一例中国IBD相关AA患者的病例，并回顾有关潜在IBD的AA的文献。我们报告了一例48岁男性患者，其左手和肺部有多处AA，经泼尼松成功治疗。在过去2年里，他曾接受过两次皮肤脓肿切开引流术。该患者因溃疡性结肠炎和左手背部疼痛前来我院就诊。手部脓液和血培养显示为无菌性皮肤脓肿。住院期间胸部计算机断层扫描检查发现有肺脓肿。AA对头孢替安或头孢哌酮 - 舒巴坦无反应。直到使用泼尼松后，患者左手和肺部情况才有所改善。患者门诊随访3个月，康复且无任何临床症状。我们从文献中检索到17例IBD相关AA病例。所有患者均无感染证据且抗生素治疗无效，使用皮质类固醇后均有改善。AA可能是IBD的一种肠外表现。有效的药物包括皮质类固醇和免疫抑制剂。该病例可能会提高对AA的认识并有助于早期识别。
