Trinh Dennison, Al Halabi Lina, Brar Harsimar, Kametani Marie, Nash Joanne E
Department of Biological Sciences, University of Toronto, Toronto, ON, Canada.
Department of Biological Sciences, University of Toronto Scarborough Graduate Department of Cells Systems Biology, University of Toronto Cross-Appointment with Department of Psychology, University of Toronto Scarborough Scientist - KITE, Toronto, ON, Canada.
Front Cell Neurosci. 2024 Aug 2;18:1434459. doi: 10.3389/fncel.2024.1434459. eCollection 2024.
Mitochondria are responsible for maintaining cellular energy levels, and play a major role in regulating homeostasis, which ensures physiological function from the molecular to whole animal. Sirtuin 3 (SIRT3) is the major protein deacetylase of mitochondria. SIRT3 serves as a nutrient sensor; under conditions of mild metabolic stress, SIRT3 activity is increased. Within the mitochondria, SIRT3 regulates every complex of the electron transport chain, the tricarboxylic acid (TCA) and urea cycles, as well as the mitochondria membrane potential, and other free radical scavengers. This article reviews the role of SIRT3 in regulating homeostasis, and thus physiological function. We discuss the role of SIRT3 in regulating reactive oxygen species (ROS), ATP, immunological function and mitochondria dynamics.
线粒体负责维持细胞能量水平，并在调节体内平衡中发挥主要作用，体内平衡确保了从分子水平到整个动物体的生理功能。沉默调节蛋白3（SIRT3）是线粒体的主要蛋白质脱乙酰酶。SIRT3作为一种营养传感器；在轻度代谢应激条件下，SIRT3的活性会增加。在线粒体内，SIRT3调节电子传递链、三羧酸（TCA）循环和尿素循环的每一个复合体，以及线粒体膜电位和其他自由基清除剂。本文综述了SIRT3在调节体内平衡从而调节生理功能方面的作用。我们讨论了SIRT3在调节活性氧（ROS）、三磷酸腺苷（ATP）、免疫功能和线粒体动力学方面的作用。
