Singh Harkanwal P, Chahal Gagandeep K, Sharma Geeta, Gandhi Piyush
Department of Oral Pathology and Microbiology, Dasmesh Institute of Research and Dental Sciences, Faridkot, India.
Department of Prosthodontics, National Dental College Derra Bassi, Mohali, Punjab, India.
J Oral Maxillofac Pathol. 2024 Apr-Jun;28(2):268-274. doi: 10.4103/jomfp.jomfp_460_23. Epub 2024 Jul 11.
There are still certain gaps in the research that need to be filled despite the fact that numerous studies have looked into the transformation of odontogenic cysts into neoplastic lesions. To identify pertinent research that had been published and to synthesise the available data and provide an overview of the current body of knowledge, this review also sought to do so.
Adopting the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a search strategy was implemented across several online databases to search for relevant articles as per the defined selection criterion.
After the search strategy was complete, 31 studies were chosen. Men tended to have more cancer than women. Swelling and discomfort were the primary pathology-related complaints. Although two cases were not detailed, radiologically, well-defined and poorly defined borders were reported in 18 and 11 participants, respectively. Squamous cell carcinoma with good differentiation ( = 12) was the most common cancer kind. More than 74% of patients were still living 6 months to 10 years following follow-up, four (12.90%) experienced recurrences and/or metastases and two (6.45%) experienced a disease-related mortality between 2 months and a year.
Prompt surgical follow-ups and cautious excision of odontogenic cysts are essential to avoiding neoplastic change and recurrence. Future research is required to look at possible reasons why odontogenic cysts can convert neoplastically.
尽管已有大量研究探讨牙源性囊肿向肿瘤性病变的转变，但仍存在一些需要填补的研究空白。本综述旨在识别已发表的相关研究，综合现有数据并概述当前的知识体系。
采用系统评价和Meta分析的首选报告项目（PRISMA）指南，在多个在线数据库中实施检索策略，以根据定义的选择标准搜索相关文章。
检索策略完成后，选择了31项研究。男性患癌人数往往多于女性。肿胀和不适是与病理相关的主要主诉。尽管有两例未详细说明，但在影像学上，分别有18名和11名参与者报告了边界清晰和边界不清的情况。高分化鳞状细胞癌（n = 12）是最常见的癌症类型。随访6个月至10年后，超过74%的患者仍存活，4例（12.90%）出现复发和/或转移，2例（6.45%）在2个月至1年之间出现与疾病相关的死亡。
及时进行手术随访和谨慎切除牙源性囊肿对于避免肿瘤性改变和复发至关重要。未来需要研究牙源性囊肿发生肿瘤性转变的可能原因。
