Resident and PhD Student, Oral & Maxillofacial Surgery Department, Thomas Jefferson University Hospital, Philadelphia, PA.
Assistant Professor, Oral & Maxillofacial Surgery Department, Thomas Jefferson University Hospital, Philadelphia, PA.
J Oral Maxillofac Surg. 2021 May;79(5):1081.e1-1081.e9. doi: 10.1016/j.joms.2020.12.046. Epub 2021 Jan 1.
To assess the prognostic findings of the carcinomatous transformation of odontogenic keratocyst (OKC).
A systematic review of all cases of carcinomatous transformation of OKC was completed, and a case report was included.
A total of 679 publications were screened, and 37 cases met inclusion criteria. The mean age for patients with malignant transformation of OKC was 45.1 years. Pain (67.5%) and swelling (78.3%) were the most common symptoms. The malignant transformation occurred with increased frequency in the posterior mandible and larger lesions that span greater than 2 subunits of the involved jaw. Resection was the definitive treatment in all cases and 14 cases (46%) utilized adjuvant treatment.
Patient outcomes and follow-up was variable in our study such that overall survival was difficult to determine. However, overall survival in malignant transformation of odontogenic cysts of all kinds ranges from 62 to 85% and 30 to 8% for 2 and 5 years, respectively.
评估牙源性角化囊性瘤（OKC）癌变的预后发现。
对所有 OKC 癌变病例进行了系统回顾，并纳入了一个病例报告。
共筛选出 679 篇文献，符合纳入标准的病例有 37 例。OKC 恶性转化患者的平均年龄为 45.1 岁。疼痛（67.5%）和肿胀（78.3%）是最常见的症状。恶性转化在后颌骨和跨越受累颌骨 2 个以上单位的较大病变中更常见。所有病例均采用切除术作为明确的治疗方法，其中 14 例（46%）采用辅助治疗。
在我们的研究中，患者的预后和随访情况各不相同，因此总体生存率难以确定。然而，牙源性囊肿恶变的总体生存率为 2 年时为 62%至 85%，5 年时为 30%至 8%。
