Jahagirdar Pramod, Vaishnav Kalpesh, Sarathy Niharika Abhay, Singh Harneet, Kumia Komal, Banerjee Abhishek
Department of Dentistry, Karnavati School of Research, Gandhinagar, Gujarat, India.
Department of Prosthodontics, Crown, and Bridge, Karnavati School of Dentistry, Gujarat, India.
J Oral Maxillofac Pathol. 2024 Apr-Jun;28(2):205-210. doi: 10.4103/jomfp.jomfp_28_24. Epub 2024 Jul 11.
The global outbreak of coronavirus disease 2019 (COVID-19) presents numerous obstacles for healthcare professionals. The present study aimed to evaluate and compare the role of serum biomarkers like- C-reactive protein (CRP), interleukin-6 (IL-6), and D-dimers in the severity of COVID-19 infection.
A cross-sectional, observational retrospective pilot study was conducted in Udaipur, Rajasthan, wherein data was collected from 250 subjects, out of which, data of 100 subjects were included as per the inclusion criteria. The data was recorded retrospectively among the health professionals via Google Forms in Udaipur, Rajasthan.
There were 1 (1%), 3 (3%), 31 (31%) and 65 (65%) participants with minor elevation (0.3-1.0), moderate elevation (1-10), marked elevation (10-50) and severe elevation (>50) of CRP respectively. The difference between the groups was statistically highly significant with a significantly higher number of study participants with a severe elevation of CRP levels (χ = 107.84, < 0.001). The results showed that there was a significant difference between the groups with IL6 in 0-7 range while 96 (96%) study participants had >7 IL6, and the difference was statistically highly significant (2 = 84.640, 0.001).
In conclusion, the existing body of research indicates a discernible correlation between COVID-19 infection and the fluctuation of biomarker levels. This supplement has the potential to be utilised in clinical practice as a means of informing treatment decisions and determining the necessity of admission to the intensive care unit (ICU).
2019年冠状病毒病（COVID-19）的全球爆发给医护人员带来了诸多障碍。本研究旨在评估和比较血清生物标志物如C反应蛋白（CRP）、白细胞介素-6（IL-6）和D-二聚体在COVID-19感染严重程度中的作用。
在拉贾斯坦邦乌代布尔进行了一项横断面、观察性回顾性试点研究，从250名受试者中收集数据，其中100名受试者的数据符合纳入标准。数据通过谷歌表单在拉贾斯坦邦乌代布尔的卫生专业人员中进行回顾性记录。
CRP轻度升高（0.3 - 1.0）、中度升高（1 - 10）、显著升高（10 - 50）和重度升高（>50）的参与者分别有1名（1%）、3名（3%）、31名（31%）和65名（65%）。组间差异具有高度统计学意义，CRP水平重度升高的研究参与者数量显著更多（χ = 107.84，< 0.001）。结果显示，IL6在0 - 7范围内的组间存在显著差异，而96名（96%）研究参与者的IL6 >7，差异具有高度统计学意义（2 = 84.640，0.001）。
总之，现有研究表明COVID-19感染与生物标志物水平波动之间存在明显关联。本补充材料有潜力在临床实践中用于指导治疗决策和确定入住重症监护病房（ICU）的必要性。
