Design, synthesis, docking studies and bioactivity evaluation of 1,2,3-triazole eugenol derivatives.

The design, synthesis, docking studies and evaluation of the antifungal and cytotoxic properties of eugenol (EUG) containing 1,2,3-triazole derivatives are reported. Most of the derivatives have not been reported. The EUG derivatives were synthesized, molecular docked and tested for their antifungal activity. The compounds showed potent antifungal activity against , associated with dermatophytosis. Compounds and exhibited promising results, with being four-times more potent than EUG. The binding mode prediction was similar to itraconazole in the lanosterol-14-α-demethylase wild-type and G73E mutant binding sites. Additionally, the pharmacokinetic profile prediction suggests good gastrointestinal absorption and potential oral administration. Compound is a promising antifungal agent against dermatophytosis caused by .