Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA.
Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, and Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, Nanjing Forestry University, Nanjing 210037, China.
Curr Opin Biotechnol. 2021 Jun;69:232-241. doi: 10.1016/j.copbio.2021.02.001. Epub 2021 Feb 25.
Natural products are specialized small molecules produced in Nature and play pivotal roles in many cellular processes. These compounds possess exquisite chemical diversity and represent some of the most important pharmaceutical agents in human health care. With the rampant rise of fungal pathogens that are becoming resistant to nearly all clinically available antibiotics, there is an increased urgency to find new antifungal therapies with novel modes of action. To meet this need, we must be able to quickly identify new bioactive chemical scaffolds within complex natural extracts, determine their mechanisms of action, and generate appreciable yields for preclinical studies. In this review, we will highlight naturally derived antifungal agents of clinical importance as well as those with strong potential as leads in drug development.
天然产物是在自然界中产生的具有生物活性的小分子，在许多细胞过程中发挥关键作用。这些化合物具有精致的化学多样性，是人类保健中一些最重要的药物制剂。由于真菌病原体的猖獗增长，它们几乎对所有临床可用的抗生素都产生了耐药性，因此迫切需要找到具有新型作用机制的新抗真菌疗法。为了满足这一需求，我们必须能够快速在复杂的天然提取物中识别新的具有生物活性的化学支架，确定它们的作用机制，并为临床前研究生成可观的产量。在这篇综述中，我们将重点介绍具有临床重要性的天然来源的抗真菌药物，以及那些具有药物开发潜力的先导化合物。
