Catalytic Asymmetric Reductive Amination for Axially Chiral Aryl Aldehydes via Desymmetrization/Kinetic Resolution Cascade.
作者信息
Wang Yi, Song Rui-Ping, Li Xin-Yue, Chen Wen-Li, Tian Yu, Zhang Shu-Hui, Shao You-Dong, Cheng Dao-Juan
机构信息
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
School of Chemistry and Chemical Engineering, Heze University, Heze 274015, China.
出版信息
Org Lett. 2024 Aug 30;26(34):7161-7165. doi: 10.1021/acs.orglett.4c02540. Epub 2024 Aug 19.
PMID:39158186
Abstract
Herein we present an efficient chiral phosphoric-acid-catalyzed atropoenantioselective asymmetric reductive amination of biaryl dialdehydes. The process involves desymmetrization and the following kinetic resolution, with a wide range of axially chiral aryl aldehydes obtained with high optical purities.
摘要
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