Gauld Christophe, Fourneret Pierre, Alderson-Day Ben, Palmer-Cooper Emma, Dondé Clément
Service de Psychopathologie du Développement, Hospices Civils de Lyon, Lyon, France. Institut des Sciences Cognitives Marc Jeannerod, Unité Mixte de Recherche 5229, Centre National de la Recherche Scientifique & Université Claude Bernard Lyon 1, Lyon, France.
Department of Psychology, Durham University, Durham, UK.
Braz J Psychiatry. 2025;47:e20243614. doi: 10.47626/1516-4446-2024-3614. Epub 2024 Aug 19.
Patients at risk of psychosis present a variety of symptoms, and identifying the most discriminative symptoms is essential for efficient detection and treatment.
This cross-sectional online study analyzed individuals from the general population to better assess their risk of symptoms classified as clinical high risk (CHR) for psychosis. The 16-item Prodromal Questionnaire was applied as a self-report screening tool. Item response theory with a graded response model was used to assess the discrimination and difficulty of the questionnaire's criteria.
The analysis included 936 participants (mean age: 21.5 years; 71.9% women). "Déjà vu" stood out for its high discriminative power, while the "voices or whispers" and "seeing things" items had greater precision than the other CHR-related symptoms. Conversely, the "smell or taste" and "changing faces" items were associated with the most severe cases.
This study identified the most indicative CHR-related symptoms for accurate assessment of psychosis severity, which can be used to guide targeted preventative interventions.
有精神病风险的患者会出现多种症状，识别最具区分性的症状对于有效检测和治疗至关重要。
这项横断面在线研究分析了来自普通人群的个体，以更好地评估他们出现被归类为精神病临床高危（CHR）症状的风险。使用16项前驱症状问卷作为自我报告筛查工具。采用带有等级反应模型的项目反应理论来评估问卷标准的区分度和难度。
分析纳入了936名参与者（平均年龄：21.5岁；71.9%为女性）。“似曾相识”因其高区分度而突出，而“听到声音或低语”和“看到东西”项目比其他与CHR相关的症状具有更高的精准度。相反，“嗅觉或味觉”和“面孔变化”项目与最严重的病例相关。
本研究确定了与CHR相关的最具指示性的症状，用于准确评估精神病严重程度，可用于指导有针对性的预防干预措施。
