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医学治疗、基因选择与基因编辑:超越影响个人与非个人理由的区分

Medical Treatment, Genetic Selection, and Gene Editing: Beyond the Distinction Between Person-Affecting and Impersonal Reasons.

作者信息

Żuradzki Tomasz

机构信息

Jagiellonian University.

出版信息

Am J Bioeth. 2024 Aug;24(8):50-52. doi: 10.1080/15265161.2024.2364691. Epub 2024 Aug 19.

DOI:10.1080/15265161.2024.2364691
PMID:39158446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7617310/
Abstract

According to what McMahan and Savulescu (2024) call the “popular position”, embryo selection is less ethically problematic than gene editing (other things being equal). The Two-Tier View, defended by McMahan and Savulescu, implies that the popular position is mistaken. The authors treat gene editing of embryos similarly to standard cases of medical treatments that promise expected benefits for the (subsequent) person even though gene editing also may create risks of harmful side effects for her. McMahan and Savulescu assume that if gene editing is (successfully) done, it is better for the person who developed from the beneficently edited embryo. And, if the editing had not been done, although it was possible, that would have been worse for the same person in question. Thus, the comparator must always be a possible, even if unlikely, world in which she would have existed. That is why gene editing, in their view, resembles medical treatments. Therefore, assuming that standard medical treatments are not more ethically problematic than embryo selection, they conclude that (in general) gene editing should also be treated as not more problematic than embryo selection.

摘要

根据麦克马汉和萨夫勒斯库(2024年)所称的“普遍观点”,在其他条件相同的情况下,胚胎选择在伦理上的问题比基因编辑要少。麦克马汉和萨夫勒斯库所捍卫的“双层观点”意味着普遍观点是错误的。作者将胚胎的基因编辑与标准的医疗案例同等看待,这些医疗案例有望为(后续的)个体带来预期益处,尽管基因编辑也可能给她带来有害副作用的风险。麦克马汉和萨夫勒斯库假定,如果基因编辑(成功)实施,那么由经过有益编辑的胚胎发育而来的个体状况会更好。而且,如果没有进行编辑,尽管有可能进行编辑,对于同一个个体来说情况会更糟。因此,比较的对象必须始终是一个可能存在的世界,即便可能性不大,在这个世界中她本可以存在。这就是为什么在他们看来,基因编辑类似于医疗治疗。所以,假设标准医疗治疗在伦理上的问题并不比胚胎选择更多,他们得出结论:(总体而言)基因编辑也应该被视为在伦理问题上不比胚胎选择更多。

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本文引用的文献

1
Reasons and Reproduction: Gene Editing and Genetic Selection.原因与繁衍:基因编辑与遗传选择。
Am J Bioeth. 2024 Aug;24(8):9-19. doi: 10.1080/15265161.2023.2250288. Epub 2023 Sep 11.
2
Gene Editing, Identity and Benefit.基因编辑、身份与益处。
Philos Q. 2021 Jun 5;72(2):305-325. doi: 10.1093/pq/pqab029. eCollection 2022 Apr.
3
Reasons to Genome Edit and Metaphysical Essentialism about Human Identity.基因组编辑的理由与关于人类身份的形而上学本质主义
Am J Bioeth. 2022 Sep;22(9):34-36. doi: 10.1080/15265161.2022.2105431.
4
Human Germline Genome Editing: On the Nature of Our Reasons to Genome Edit.人类生殖系基因组编辑:关于我们进行基因组编辑的理由的本质。
Am J Bioeth. 2022 Sep;22(9):4-15. doi: 10.1080/15265161.2021.1907480. Epub 2021 Apr 19.