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本文引用的文献

1
Human Germline Genome Editing: On the Nature of Our Reasons to Genome Edit.人类生殖系基因组编辑:关于我们进行基因组编辑的理由的本质。
Am J Bioeth. 2022 Sep;22(9):4-15. doi: 10.1080/15265161.2021.1907480. Epub 2021 Apr 19.
2
Reproductive genome editing interventions are therapeutic, sometimes.生殖系基因组编辑干预措施具有治疗作用,有时是这样。
Bioethics. 2021 Jul;35(6):557-562. doi: 10.1111/bioe.12846. Epub 2021 Feb 7.
3
Can reproductive genetic manipulation save lives?生殖遗传操纵能否拯救生命?
Med Health Care Philos. 2020 Sep;23(3):381-386. doi: 10.1007/s11019-020-09947-2.
4
Reproductive CRISPR does not cure disease.生殖性CRISPR无法治愈疾病。
Bioethics. 2019 Nov;33(9):1072-1082. doi: 10.1111/bioe.12663. Epub 2019 Sep 6.
5
An ethical pathway for gene editing.基因编辑的伦理路径。
Bioethics. 2019 Feb;33(2):221-222. doi: 10.1111/bioe.12570.
6
The Ethics of Germline Gene Editing.生殖系基因编辑的伦理问题。
J Appl Philos. 2017 Aug;34(4):498-513. doi: 10.1111/japp.12249. Epub 2016 Nov 9.
7
Genome editing and assisted reproduction: curing embryos, society or prospective parents?基因组编辑与辅助生殖:治愈胚胎、社会还是准父母?
Med Health Care Philos. 2018 Jun;21(2):215-225. doi: 10.1007/s11019-017-9793-y.
8
Mitochondrial Replacement: Ethics and Identity.线粒体替代:伦理与身份认同
Bioethics. 2015 Nov;29(9):631-8. doi: 10.1111/bioe.12187.
9
ASGCT and JSGT Joint Position Statement on Human Genomic Editing.美国基因与细胞治疗学会(ASGCT)和日本基因与细胞治疗学会(JSGT)关于人类基因组编辑的联合立场声明。
Mol Ther. 2015 Aug;23(8):1282. doi: 10.1038/mt.2015.118.
10
Don't edit the human germ line.不要编辑人类生殖细胞系。
Nature. 2015 Mar 26;519(7544):410-1. doi: 10.1038/519410a.

基因编辑、身份与益处。

Gene Editing, Identity and Benefit.

作者信息

Douglas Thomas, Devolder Katrien

机构信息

University of Oxford, UK.

出版信息

Philos Q. 2021 Jun 5;72(2):305-325. doi: 10.1093/pq/pqab029. eCollection 2022 Apr.

DOI:10.1093/pq/pqab029
PMID:36812016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9915102/
Abstract

Some suggest that gene editing human embryos to prevent genetic disorders will be in one respect morally preferable to using genetic selection for the same purpose: gene editing will benefit particular future persons, while genetic selection would merely replace them. We first construct the most plausible defence of this suggestion-the benefit argument-and defend it against a possible objection. We then advance another objection: the benefit argument succeeds only when restricted to cases in which the gene-edited child would have been brought into existence even if gene editing had not been employed. Our argument relies on a standard account of comparative benefit which has recently been criticised on the grounds that it succumbs to the so-called 'pre-emption problem'. We end by considering how our argument would be affected were the standard account revised in an attempt to evade this problem. We consider three revised accounts and argue that, on all three, our critique of the benefit argument stands.

摘要

一些人认为,为预防遗传疾病而对人类胚胎进行基因编辑,在某方面从道德上讲要优于出于同样目的进行基因选择:基因编辑将造福特定的未来个体,而基因选择仅仅是替换他们。我们首先构建对这一观点最合理的辩护——益处论证,并针对一个可能的反对意见为其辩护。然后我们提出另一个反对意见:益处论证只有在局限于即便未采用基因编辑该基因编辑儿童也会出生的情况下才成立。我们的论证依赖于一种关于比较益处的标准解释,该解释最近受到批评,理由是它屈服于所谓的“先占问题”。最后我们考虑,如果为规避这个问题而对标准解释进行修订,我们的论证会受到怎样的影响。我们考虑了三种修订后的解释,并论证在这三种解释下,我们对益处论证的批判都成立。