Department of Integrative and Functional Biology, CSIR- Institute of Genomics & Integrative Biology, Mall Road, Delhi, 110007, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Mol Biol Rep. 2024 Aug 19;51(1):921. doi: 10.1007/s11033-024-09849-z.
The emergence of chronic diseases, particularly cancers, cardiovascular, and bone disorders, presents a formidable challenge, as currently available synthetic drugs often result in significant side effects and incur higher costs. Phytoestrogen Bavachin, present in the Psoralea corylifolia L. plant, represents structural and functional similarity to mammalian estrogen and has recently attracted researchers for its medicinal properties. This review spotlighted the extraction methods, bioavailability and therapeutic interventions of Bavachin against diseases. Bavachin exerted estrogenic properties, demonstrating the ability to bind to estrogen receptors (ERs), mimicking the actions of human estrogen and initiating estrogen-responsive pathways. Bavachin delivered potent therapeutic ventures in abrogating chronic diseases, including cancer, neuronal, bone, cardiovascular, skin, lung, and liver disorders via targeting signaling transductions, managing calcium signaling, immune regulation, inflammation, apoptosis, and oxidative stress. In-silico analysis, including Gene ontology and pathway enrichment analysis, retrieved molecular targets of Bavachin, majorly cytochrome c oxidase (COX), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3), and ER, hypothesizing Bavachin's cellular mechanism in preventing crucial health ailments. Limitations of Bavachin were also summarized, evidenced by hepatotoxicity at specific dosage levels. In conclusion, Bavachin showed promising therapeutic efficacy in suppressing chronic diseases and can be considered as an adequate replacement for hormone replacement therapy, necessitating further investigations on its effectiveness, safety, and clinical outcomes.
慢性病的出现，特别是癌症、心血管和骨骼疾病，构成了巨大的挑战，因为目前可用的合成药物通常会导致严重的副作用，并带来更高的成本。存在于 Psoralea corylifolia L. 植物中的植物雌激素巴维辛，在结构和功能上与哺乳动物雌激素相似，最近因其药用特性引起了研究人员的关注。本综述重点介绍了巴维辛的提取方法、生物利用度和治疗干预措施，以对抗疾病。巴维辛表现出雌激素特性，能够与雌激素受体 (ER) 结合，模拟人类雌激素的作用，并启动雌激素反应途径。巴维辛通过靶向信号转导、调节钙信号、免疫调节、炎症、细胞凋亡和氧化应激，在消除癌症、神经元、骨骼、心血管、皮肤、肺和肝脏疾病等慢性疾病方面发挥了强大的治疗作用。基于计算机的分析，包括基因本体论和途径富集分析，确定了巴维辛的主要分子靶标，包括细胞色素 c 氧化酶 (COX)、核因子 kappa-轻链增强子的 B 细胞 (NF-κB)、核苷酸结合域、富含亮氨酸的家族、吡喃结构域包含 3 (NLRP3) 和 ER，推测了巴维辛在预防重要健康疾病方面的细胞机制。还总结了巴维辛的局限性，即在特定剂量水平下具有肝毒性。总之，巴维辛在抑制慢性疾病方面显示出有希望的治疗效果，可以被认为是激素替代疗法的合适替代品，需要进一步研究其有效性、安全性和临床结果。
